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Regulation of macroautophagy by mTOR and Beclin 1 complexes
Biochimie, 2008Macroautophagy or autophagy is a vacuolar degradative pathway terminating in the lysosomal compartment after forming a cytoplasmic vacuole or autophagosome that engulfs macromolecules and organelles. The original discovery that ATG (AuTophaGy related) genes in yeast are involved in the formation of autophagosomes has greatly increased our knowledge of ...
Sophie, Pattingre +3 more
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Beclin-1: Autophagic regulator and therapeutic target in cancer
The International Journal of Biochemistry & Cell Biology, 2013Beclin-1 (the mammalian ortholog of yeast ATG6) has been well-characterized to play a pivotal role in autophagy that is a major catabolic pathway in which the cell degrades macromolecules and damaged organelles. Beclin-1 structure has been identified to contain three identifiable domains, including a short Bcl-2-homology-3 (BH3) motif, a central coiled-
Lei-lei, Fu, Yan, Cheng, Bo, Liu
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Kinase crosstalk through beclin 1
Nature Reviews Molecular Cell Biology, 2013openaire +1 more source
Autophagy: Kinase crosstalk through beclin 1.
Nature reviews. Molecular cell biology, 2013openaire +1 more source