Results 121 to 130 of about 1,579,426 (313)

Becoming Criminal Transversal Performance and Cultural Dissidence in Early Modern England [PDF]

open access: yes
He maps the effects of the public theater's transformative force of transversality, such as through the criminality represented by Shakespeare, Jonson, Middleton, and Dekker, on both Elizabethan and Jacobean society and the scholarship devoted to it ...
Reynolds, Bryan.
core  

Becoming NEET [PDF]

open access: yes, 2013
Over one million young people are now NEET - Not in Education, Employment, or Training. The waste of human resource is tragic and the resultant disaffection could dangerously destabilise society.
Arnold, Christopher, Baker, Tracey
core  

Reconstructing enzyme evolution by protein engineering

open access: yesFEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler   +2 more
wiley   +1 more source

Becoming-urban, becoming-forest: a historical geography of urban forest projects in Australia [PDF]

open access: yes
In recent times, local governments in Australia's major cities have embraced the idea that the trees in their streets, parks, and private gardens are parts of a collective urban forest that can be managed to address complex policy problems and create ...
Ryan Jones (21312680)   +1 more
core  

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

open access: yesFEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi   +6 more
wiley   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

open access: yesFEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj   +3 more
wiley   +1 more source

Midwifery basics: becoming a midwife 1. Developing as a professional [PDF]

open access: yes, 2016
Becoming a midwife is the 16th series of ‘Midwifery basics’ targeted at practising midwives and midwifery students. The aim of these articles is to provide information to raise awareness of the impact of professionalism on women’s experience, consider ...
Shepherd, Jancis
core  

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

open access: yesMolecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

open access: yesMolecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge   +17 more
wiley   +1 more source

Becoming an international humanitarian aid worker / [PDF]

open access: yes, 2016
Becoming an International Humanitarian Aid Worker draws on the experiences of those currently working and those hiring people to work in humanitarian aid today, and an analysis of job postings over a 9-month period.
Reis, Chen,author.   +1 more
core  

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