Results 41 to 50 of about 1,541 (218)
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
The Effect of Hydraulic Partitioning on Prediction the Rate of Bed Load Transport in Gravel-bed Rivers using Support Vector Machine [PDF]
جغرافیا و پایداری محیط, 2019 Evaluation and prediction of sediment transport and associated processes have been one of the main issues of hydraulic and river engineers. There are some variables which affect the amount of bed load of a stream or river which may carry such as ...
Kiyoumars Roushangar +2 more
doaj
A Novel Efficient Method of Estimating Suspended‐To‐Total Sediment Load Fraction in Natural Rivers
Water Resources Research, 2023 Sediment transport load monitoring is important in civil and environmental engineering fields. Monitoring the total load is difficult, especially because of the cost of the bed load transport measurement.
Hyoseob Noh, Yong Sung Park, Il Won Seo
doaj +1 more source
Optimal biocatalyst loading in a fixed bed
Journal of Industrial Microbiology & Biotechnology, 2007 The optimal distribution of biocatalyst in a fixed bed operating at steady state was determined to minimize the length of the bed for a fixed conversion of 95%. The distribution in terms of the biocatalyst loading on an inert support depends upon the axial distance from the bed entrance (continuous solution) as well as a set of dimensionless parameters
V, Tortoriello, G B, DeLancey
openaire +2 more sources
Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola +11 more
wiley +1 more source
Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes
FEBS Open Bio, EarlyView.Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard +12 more
wiley +1 more source
Effect of bed load transport on the energy dissipation of step-pool system
Shui kexue jinzhan, 2017 Step-pool system is a typical bed micro-morphology in high gradient mountain rivers, which creates extremely high turbulence intensity and thus dissipates a majority the flow energy. The increase of the bed load transport intensity changed the flow field
LI Wenzhe, LI Zhiwei, WANG Zhaoyin
doaj +1 more source
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Onasemnogene abeparvovec (OA) is an AAV9‐based gene therapy for spinal muscular atrophy type I (SMA I). Real‐world outcomes show increased response variability compared to clinical trials, and follow‐up data beyond 12–18 months are limited.
Marika Pane +43 more
wiley +1 more source
Sediment Transport Analysis of Sesayap River, Malinau District, North Kalimantan
Journal of the Civil Engineering Forum, 2017 River could have a very important role in improving the economy of a country when it is correctly and properly utilized. Nevertheless, rivers in Indonesia also have various problems, i.e.
Hardhi Rafsanjani
doaj +1 more source
A Two‐Stage Questionnaire and Actigraphy Screening for iRBD in a Multicenter Retrospective Cohort
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Isolated rapid‐eye‐movement sleep behavior disorder is a prodromal marker of synucleinopathies. However, most cases remain undiagnosed due to the insufficient predictive value of questionnaires and limited access to confirmatory video‐polysomnography. We assessed a two‐stage screening strategy combining a brief questionnaire on rapid‐
Caleb A. Massimi +17 more
wiley +1 more source