Results 161 to 170 of about 3,652,993 (292)

Targeting CXCR2 in Nociceptive Sensory Neurons Offers Novel Therapeutic Potentials for Postoperative Pain

open access: yesAdvanced Science, EarlyView.
Tissue incision induces CXCL5 release, which activates neuronal CXCR2 on incision‐innervating sensory neurons. Neuronal CXCR2 couples with TRPA1 to drive mechanical pain and engages p38 MAPK signaling to upregulate TRPV1 and promote heat pain. Targeted Cxcr2 knockdown relieves incisional pain while preserving CXCR2‐dependent neutrophil responses ...
Yushuang Pan   +10 more
wiley   +1 more source

3D Printed Meter‐Scale Soft Origami Robots Capable of Load‐Bearing Actuation Via Crease Stiffness Modulation

open access: yesAdvanced Science, EarlyView.
Origami has inspired numerous soft deployable mechanisms for safe human‐robot interaction, while its intrinsic kinematic instability at arbitrary configurations limited their practical robotic application. This work presents a 3D printed meter‐scale origami robotic actuator capable of load‐bearing deformation through creaseline stiffness modulation.
Sung Yol Yu   +5 more
wiley   +1 more source

Dual‐Responsive Hydrogels Integrate Bioelectrical Stimulation and Piezo‐Photocatalysis for Regenerative Treatment of Infected Wounds

open access: yesAdvanced Science, EarlyView.
A wireless, dual‐responsive hydrogel (PVA/(PVDF‐TrFE)/BiOClBr@PDA) is developed to promote efficient regeneration of infected wounds by integrating piezoelectric stimulation with piezo‐photocatalytic pathways. Under simultaneous light and ultrasonic stimulation, the hydrogel generates therapeutic electrical cues and reactive oxygen species, disrupting ...
Baoying Dai   +15 more
wiley   +1 more source

Modelling the transport and deposition of sediment-microplastics fluxes in a braided river, using Delft3D. [PDF]

open access: yesPhilos Trans A Math Phys Eng Sci
Alvarez Barrantes L   +5 more
europepmc   +1 more source

Entorhinal Astrocyte Transplants Restore Spatial Exploration and Alleviate Amyloid‐Beta Pathology in Alzheimer's Mice

open access: yesAdvanced Science, EarlyView.
Impaired MEC astrocytic Ca2+ signaling is associated with fragmented spatial exploration in AD mice. Region‐specific glial progenitor transplantation generates engrafted astrocytes that are accompanied by improved AQP4 polarization, reduced amyloid‐β‐associated pathology, attenuated neuroinflammation, preserved synaptic integrity, and ameliorated ...
Fengjuan Wu   +16 more
wiley   +1 more source

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