Results 91 to 100 of about 5,611,372 (241)

ZBTB18 Dysfunction Promotes Neuropathic Pain via CHD4‐based Epigenetic Disinhibition of CLIC1 Channels in Sensory Neurons

Advanced Science, EarlyView.
In this study, we identify a novel functional role of ZBTB18 in regulating trigeminal‐mediated neuropathic pain. Nerve injury reduces ZBTB18 in trigeminal ganglion neurons, impairing CHD4/NuRD recruitment and de‐repressing Clic1. Elevated CLIC1 enhances chloride channel activity and neuronal hyperexcitability, thereby driving pain.
Shoupeng Wang, Zitong Huang, Yu Tao, Yunmei Zhang, Yufang Sun, Dongsheng Jiang, Weiwei Lu, Fuhai Ji, Gang Chen, Min Xu, Yuan Zhang, Jin Tao   +11 more
wiley   +1 more source

Bed utilisation trends in selected wards across eight district hospitals in the Cape Town district [PDF]

, 2018
Master of Public Health - MPHBackground: The largest focus areas for the department of health is ensuring access to quality healthcare. The district health system (DHS) model remains the vehicle used by the district managers to deliver on the health ...
Najjaar, Leilah
core  

Leveraging Microphysiological Systems to Facilitate Neutrophil‐Based Cancer Immunotherapy

Advanced Science, EarlyView.
Microphysiological systems are emerging as powerful human‐relevant platforms for studying neutrophil biology in cancer. Current applications of spheroids, organoids, and organ‐on‐a‐chip models are reviewed, together with future opportunities in behaviorome profiling, multi‐omics integration, personalized medicine, immune crosstalk, and multi‐organ ...
Shuai Shao, Markus Isfeld Diehl, Caroline N. Jones   +2 more
wiley   +1 more source

Performance indicators of hospitals affiliated to Health Network in East Azerbaijan before and after health reform

Payesh, 2018
Objective (s): Health reform in Iran focuses on improvements in various areas health system such as different hospital indicators. This study aimed to investigate the effects of the new health transformational plan  on the performance indicators. Methods:
Javid Ghazizadeh, Yeganeh Partovi, Saeideh Alidoost, Nesa Kavakebi   +3 more
doaj  

Comparison of some hospital indicators before and after the implementation of the transformation plan in training hospitals affiliated to Zabol University of Medical Sciences

Majallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Qum, 2021
Background and Objectives: The health sector evolution plan was implemented in 2014 with three approaches financial protections of people, establishing justice in access to health services and improving quality of services in hospitals.
Monire Shamsaii, Mohammadjavad Shamsaii, Sorosh Mohammdnezhad, Reyhane Bahlgardi, Parvaneh Esfahani   +4 more
doaj  

Glucocorticoid Receptor Signaling in Myeloid Cells Orchestrates Inflammation Resolution and Muscle Repair

Advanced Science, EarlyView.
Glucocorticoids (GC) are widely used to reduce inflammation. We show that the glucocorticoid receptor in myeloid cells regulates macrophage cell cycle and genome integrity during muscle regeneration. We demonstrate that dexamethasone administration during the early inflammatory phase delays muscle repair by increasing macrophage proliferation ...
Sirine Souali‐Crespo, Joe G. Rizk, Emilia Calvano, Rajesh Sahu, Emina Colovic, Imane Chabba, Valentine Gilbart, Erwan Grandgirard, Bastien Morlet, Qingshuang Cai, Daniel Metzger, Delphine Duteil   +11 more
wiley   +1 more source

Assessing performance of Guilan university hospitals (2012)

The Journal of Qazvin University of Medical Sciences, 2016
Background: Performance assessment could provide information to control and monitor of the current status and activities in hospitals. Objective: To assess the performance of hospitals affiliated with Guilan University of Medical Sciences in 2012 ...
M. Alijanzadeh, S.Gholami , SA. Moosaniaye Zare, S. Asefzadeh   +3 more
doaj  

Impact of lockdown on bed occupancy rate in a referral hospital during the COVID-19 pandemic in northeast Brazil. [PDF]

Braz J Infect Dis, 2020
Lino DODC, Barreto R, Souza FD, Lima CJM, Silva Junior GBD.   +4 more
europepmc   +1 more source

Smart Bioinks for 4D Bioprinting: Requirements, Design, and Applications

Advanced Science, EarlyView.
Smart bioinks empower 4D‐bioprinted constructs to dynamically adapt and remodel in response to stimuli, effectively biomimicking native tissues. Artificial Intelligence (AI) and Machine Learning (ML) play a guiding role in their rational design by optimizing relevant properties.
Shangsi Chen, Jiahui Lai, Qiongjiao Zeng, Liangbin Zhou, Boguang Yang, Bin Zhang, Min Wang, Jiajing Zhou, Kieran Lau, Khoon S. Lim, Zhong Alan Li, Rocky S. Tuan   +11 more
wiley   +1 more source

CHD8‐Dependent Chromatin Licensing Sustains Trophoblast Stem Cell Transcriptional Programs

Advanced Science, EarlyView.
In this study, Huang et al., identify chromatin remodeler CHD8 as an essential factor in TSC maintenance and placental development. CHD8‐dependent chromatin accessibility supports the occupancy of key trophoblast TFs and is coupled to KMT2A‐associated H3K4me3 deposition at TSC stem and cell cycle genes, providing a permissive chromatin environment for ...
Yuanyuan Huang, Zhenhua Hu, Jiali Liao, Lijun Huang, Jinyu Liu, Chen Tu, Yuchen Li, Lulu Xie, Shilei Bi, Xiaobo Fang, Jingsi Chen, Lili Du, Wei Sun, Haibin Wang, Shuang Zhang, Dunjin Chen, Zhaowei Tu   +16 more
wiley   +1 more source