Results 1 to 10 of about 974,343 (355)

Retinal venular vessel diameters are smaller during ten days of bed rest [PDF]

Scientific Reports, 2023
Older individuals experience cardiovascular dysfunction during extended bedridden hospital or care home stays. Bed rest is also used as a model to simulate accelerated vascular deconditioning occurring during spaceflight.
Adam Saloň, Göktuğ Mert Çiftci, Damir Zubac, Boštjan Šimunič, Rado Pišot, Marco Narici, Per Morten Fredriksen, Benedicta Ngwenchi Nkeh-Chungag, Harald Sourij, Omar Šerý, Karin Schmid-Zalaudek, Bianca Steuber, Patrick De Boever, Nandu Goswami   +13 more
doaj   +2 more sources

Effects of Hypoxia and Bed Rest on Markers of Cardiometabolic Risk: Compensatory Changes in Circulating TRAIL and Glutathione Redox Capacity [PDF]

Frontiers in Physiology, 2018
In chronic diseases, hypoxia and physical inactivity are associated with atherosclerosis progression. In contrast, a lower mortality from coronary artery disease and stroke is observed in healthy humans residing at high altitude in hypoxic environments ...
Gianni Biolo, Filippo G. Di Girolamo, Adam McDonnell, Nicola Fiotti, Filippo Mearelli, Roberta Situlin, Arianna Gonelli, Barbara Dapas, Mauro Giordano, Mitja Lainscak, Gabriele Grassi, Giorgio Zauli, Paola Secchiero, Igor Mekjavic   +13 more
doaj   +2 more sources

Initial Glutathione Depletion During Short-Term Bed Rest: Pinpointing Synthesis and Degradation Checkpoints in the γ-Glutamyl Cycle [PDF]

Antioxidants
Hypokinesia triggers oxidative stress and accelerates the turnover of the glutathione system via the γ-glutamyl cycle. Our study aimed to identify the regulatory checkpoints controlling intracellular glutathione levels.
Filippo Giorgio Di Girolamo, Filippo Mearelli, Mariella Sturma, Nicola Fiotti, Kaja Teraž, Alja Ivetac, Alessio Nunnari, Pierandrea Vinci, Boštjan Šimunič, Rado Pišot, Gianni Biolo   +10 more
doaj   +2 more sources

Hypoxia Worsens Affective Responses and Feeling of Fatigue During Prolonged Bed Rest [PDF]

Frontiers in Psychology, 2018
Previous research, although limited, suggests that both hypoxia and bed rest influence psychological responses by exaggerating negative psychological responses and attenuating positive emotions.
Nektarios A. M. Stavrou, Nektarios A. M. Stavrou, Tadej Debevec, Tadej Debevec, Ola Eiken, Igor B. Mekjavic, Igor B. Mekjavic   +6 more
doaj   +2 more sources

Mitochondrial Sensitivity to Submaximal [ADP] Following Bed Rest: A Novel Two-Phase Approach Associated With Fibre Types. [PDF]

J Cachexia Sarcopenia Muscle
Zuccarelli L, De Martino M, Filippi A, Knapton AE, Thackray BD, Baldassarre G, Šimunič B, Pišot R, Sirago G, Monti E, Narici M, Isola M, Murray AJ, Lippe G, Grassi B.   +14 more
europepmc   +3 more sources

Changes in real-world walking speed following 60-day bed-rest [PDF]

npj Microgravity
The aim of this work was to explore whether real-world walking speed (RWS) would change as a consequence of 60-day bed-rest. The main hypothesis was that daily RWS would decrease after the bed-rest, with a subsequent recovery during the first days of re ...
Marcello Grassi, Fiona Von Der Straten, Charlotte Pearce, Jessica Lee, Marcin Mider, Uwe Mittag, Wolfram Sies, Edwin Mulder, Martin Daumer, Jörn Rittweger   +9 more
doaj   +2 more sources

Cerebral blood flow adaptations following 90 days head-down bed rest: Evidence from pseudo-continuous arterial spin labeling magnetic resonance imaging. [PDF]

J Cereb Blood Flow Metab
Liu Y, Ren P, Cai L, Li K, Xu Z, Lv K, Li Z, Qiao P, Wang L, Luo D, Qu L, Li Y, Wang Z.   +12 more
europepmc   +3 more sources

Capillary rarefaction during bed rest is proportionally less than fibre atrophy and loss of oxidative capacity

Journal of Cachexia, Sarcopenia and Muscle, 2022
Background Muscle disuse from bed rest or spaceflight results in losses in muscle mass, strength and oxidative capacity. Capillary rarefaction may contribute to muscle atrophy and the reduction in oxidative capacity during bed rest.
Paul William Hendrickse, Rob C.I. Wüst, Bergita Ganse, Ifigeneia Giakoumaki, Jörn Rittweger, Alessandra Bosutti, Hans Degens   +6 more
doaj   +1 more source

The effect of short‐term exercise prehabilitation on skeletal muscle protein synthesis and atrophy during bed rest in older men

Journal of Cachexia, Sarcopenia and Muscle, 2021
Background Poor recovery from periods of disuse accelerates age‐related muscle loss, predisposing individuals to the development of secondary adverse health outcomes.
Benoit Smeuninx, Yasir S. Elhassan, Konstantinos N. Manolopoulos, Elizabeth Sapey, Alison B. Rushton, Sophie J. Edwards, Paul T. Morgan, Andrew Philp, Matthew S. Brook, Nima Gharahdaghi, Kenneth Smith, Philip J. Atherton, Leigh Breen   +12 more
doaj   +1 more source

The Aging Muscle in Experimental Bed Rest: A Systematic Review and Meta-Analysis

Frontiers in Nutrition, 2021
Background: Maintaining skeletal muscle mass and function in aging is crucial for preserving the quality of life and health. An experimental bed rest (BR) protocol is a suitable model to explore muscle decline on aging during inactivity.Objective: The ...
Filippo Giorgio Di Girolamo, Filippo Giorgio Di Girolamo, Nicola Fiotti, Zoran Milanović, Zoran Milanović, Zoran Milanović, Roberta Situlin, Filippo Mearelli, Pierandrea Vinci, Boštjan Šimunič, Rado Pišot, Marco Narici, Gianni Biolo   +12 more
doaj   +1 more source