Results 31 to 40 of about 976,306 (307)

Electrocortical Evidence for Impaired Affective Picture Processing after Long-Term Immobilization [PDF]

open access: yes, 2019
The neurobehavioral risks associated with spaceflight are not well understood. In particular, little attention has been paid on the role of resilience, social processes and emotion regulation during long-duration spaceflight.
Brauns, Katharina   +5 more
core   +2 more sources

Management of HAPE with bed rest and supplemental oxygen in hospital setting at high altitude (11,500 ft): A review of 43 cases

open access: yesThe Journal of Association of Chest Physicians, 2017
Objectives: To evaluate the safety and efficacy of treating high-altitude pulmonary edema (HAPE) by bed rest and supplemental oxygen in hospital setting at high altitude.
Sanjay Singhal   +2 more
doaj   +1 more source

Clinical Insights Into Hypercalcemia of Malignancy in Childhood

open access: yesPediatric Blood &Cancer, EarlyView.
ABSTRACT Hypercalcemia of malignancy (HCM) is a rare but life‐threatening metabolic emergency in children that occurs in less than 1% of pediatric cancer cases, with a reported incidence ranging from 0.4% to 1.0% across different studies. While it is observed in 10%–20% of adult malignancies, pediatric HCM remains relatively uncommon.
Hüseyin Anıl Korkmaz
wiley   +1 more source

The effect of bed rest after intrauterine insemination on pregnancy outcome

open access: yesMiddle East Fertility Society Journal, 2015
Objective: To compare the effect of bed rest after intrauterine insemination for 5, 10 and 20 mins on the pregnancy rate. Design: Randomized controlled trial. Setting: Integrated Fertility Center and Agial Fertility Center.
Yasser Ibrahim Orief   +3 more
doaj   +1 more source

Changes in lower extremity muscle function after 56 days of bed rest [PDF]

open access: yes, 2011
Preservation of muscle function, known to decline in microgravity and simulation (bed rest), is important for successful spaceflight missions. Hence, there is great interest in developing interventions to prevent musclefunction loss.
Belavy, Daniel   +5 more
core  

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

open access: yesMolecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel   +6 more
wiley   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

open access: yesMolecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric   +10 more
wiley   +1 more source

Implications of Bed Rest for Patients with Acute Deep Vein Thrombosis: A Qualitative Study

open access: yesPatient Preference and Adherence, 2020
Jian-Mei Gong,1 Jian-Shi Du1,2 ,* Dong-Mei Han2, * 1Nursing School of Jilin University, Changchun City, Jilin Province, People’s Republic of China; 2Department of the Lymphatic and Vascular Surgery, China-Japan Union Hospital of Jilin University ...
Gong JM, Du JS, Han DM
doaj  

A Technique of Forced Expiratory Noise Time Evaluation Provides Distinguishing Human Pulmonary Ventilation Dynamics During Long-Term Head-Down and Head-Up Tilt Bed Rest Tests Simulating Micro and Lunar Gravity

open access: yesFrontiers in Physiology, 2018
Estimating the effect of microgravity/hypogravity on pulmonary ventilation function remains topical. Recently developed acoustic techniques based on the evaluation of the forced expiratory noise time (FETa) were hypothesized to be a promising tool for ...
Veronika V. Malaeva   +6 more
doaj   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

open access: yesMolecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau   +8 more
wiley   +1 more source

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