Results 101 to 110 of about 82,313 (293)

Reconstruction of a 3D Bedrock Model in an Urban Area Using Well Stratigraphy and Geophysical Data: A Case Study of the City of Palermo

Geosciences
A multidisciplinary approach was employed to construct a three-dimensional model of the bedrock top surface within the Palermo Plain, Sicily, Italy. This urban area is characterized by a dense and extensive built environment that largely obscures its ...
Alessandro Canzoneri, Raffaele Martorana, Mauro Agate, Maurizio Gasparo Morticelli, Patrizia Capizzi, Alessandra Carollo, Attilio Sulli   +6 more
doaj   +1 more source

Strength and erosion mechanism of soft bedrock under high shear stresses

MATEC Web of Conferences, 2016
Bedrock erosion plays a critical role in mountain river channel evolution, especially, where there are hydro-projects with high velocity flow conditions.
Li Zhijing, Jin Zhongwu
doaj   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Effects of IGFBP4 deficiency on human preadipocyte proliferation and differentiation through the IGF1R/AKT pathway

FEBS Open Bio, EarlyView.
IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo, Sandy Richter, Christoph Bach, Wieland Kiess, Anna Kirstein, Diana Le Duc, Antje Garten   +6 more
wiley   +1 more source

Drilling Fluid Technology for Ultra-High Temperature Fractured Bedrock Reservoirs

Zuanjingye yu wanjingye
The Kunteyi gas field is located in the #1 buried structure of the Kunteyi sag on the northern margin of the Qaidam Basin, the bedrock reservoirs of which are developed with fractures and have a weathering crust, and the formations of which have weak ...
Shaojun HAO, Xing XING, Xiaoxu AN, Shijun WEI, Jun ZOU, Tian HAO   +5 more
doaj   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Malformin A1–mediated cytotoxicity in ovarian cancer cells occurs through pyroptosis and autophagy

FEBS Open Bio, EarlyView.
This study investigated the effects of the natural compound Malformin A1 (MA1) on the cytoskeleton that regulates cell proliferation and migration. Disruption of the cytoskeleton can impair these processes and promote cancer cell death. MA1 disrupted cytoskeletal organization, induced DNA damage, inflammation, activated autophagy, and pyroptosis ...
Nada Abdullah Hassan, Ikram A. Burney, Shika Hanif Malgundkar, Siva Ramamoorthy, Ressin Varghese, Mohamed A. Al‐Kindi, Hamad Al Riyami, Shadia Al Bahlani, Sergey Dobretsov, Syed Imran Hassan, Benjamin K. Tsang, Yahya Tamimi   +11 more
wiley   +1 more source

Ice drilling on Princess Elizabeth Land (East Antarctica) aimed to study bedrock and Late Quaternary paleoclimate

Лëд и снег
Targeted bedrock sampling was carried out on Princess Elizabeth Land (30 km south of the coast, at 69.585591° S; 76.385165° E) by drilling through 545 m thick ice.
G. L. Leitchenkov, P. G. Talalay, N. Zhang, I. A. Abdrachmanov, M. A. Vorobyov, D. Gong, Y. Liu, Y. Li, Y. Sun, I. I. Lavrentiev, A. A. Ekaykin, D. R. Khalimov, B. Li, V. Y. Lipenkov   +13 more
doaj   +1 more source

Exploring the influence of lactoferrin on wound healing and related signaling pathways: a systematic review

FEBS Open Bio, EarlyView.
Lactoferrin promotes wound healing by activating MAPK, PI3K/Akt, and extracellular matrix pathways, enhancing fibroblast remodeling, proliferation, and re‐epithelialization. These mechanisms highlight its therapeutic potential in inflammation control, tissue repair, and remodeling.
Morgana Lüdtke Azevedo, Kátia Cristiane Hall, Matheus dos Santos Fernandez, Geovanna Peter Corrêa, Rafael Guerra Lund   +4 more
wiley   +1 more source

Physics-Constrained Machine Learning Modeling for Geotechnical Data Prediction: Case Study on Site Soil Type and Bedrock Depth Datasets

Geotechnics
This study investigates how incorporating physical constraints can enhance the performance of machine learning models by ensuring that geotechnical drilling data predictions align with known physical conditions at the site.
Yunfeng Zhang, Ahmet Darilmaz
doaj   +1 more source