Results 81 to 90 of about 82,313 (293)
Cancer‐associated mutations in endometriosis reframe a benign disease through molecular oncology
Molecular Oncology, EarlyView.This review aims to comprehensively analyse cancer‐associated somatic mutations (CAMs) present in endometriotic lesions, emphasizing their biological roles, spatial distribution and implications for translational applications in medicine. By contextualizing a benign state within a genomic framework, this analysis seeks to establish its value as a ...
Clarissa Mujacic +15 more
wiley +1 more source
Molecular Oncology, EarlyView.This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi +6 more
wiley +1 more source
, 2019 Bedrock Flowhttps://digitalmaine.com/mgs_geologic_field_photos/3036/thumbnail ...
core +1 more source
, 2019 Bedrock Jointinghttps://digitalmaine.com/mgs_geologic_field_photos/6096/thumbnail ...
core +1 more source
Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer
Molecular Oncology, EarlyView.Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim +7 more
wiley +1 more source
The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer
Molecular Oncology, EarlyView.Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad +2 more
wiley +1 more source
A combination of seismic refraction and ambient noise methods to detect landslide-prone materials
Geofísica InternacionalA portion of the west of Mexico City is densely populated in an abrupt topography, whose volcano-sedimentary materials increase the likelihood of landslides.
Martín Cárdenas-Soto +5 more
doaj +1 more source
Effect of bedrock terrain on seismic ground motion
Yantu gongcheng xuebao, 2017 Based on theoretical analysis, the spectral element method is used to study the effect of bedrock terrain on ground motion. The achievements are as follows: (1) The intensity of bedrock ground motion is related to bedrock occurrence, incident orientation
LI Xiao-bo , BO Jing-shan , WANG Xin , WAN Wei
doaj +1 more source
The Biblical World, 1917 When a pastor looks for a basis of religious faith, his interest is not academic, but practical. He is out to help his parishioners to a real living faith. It is this which gives interest to the present article. It is the result of the thinking engendered by actual pastoral experience.
openaire +1 more source
Molecular Oncology, EarlyView.In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico +5 more
wiley +1 more source