Results 51 to 60 of about 1,709,689 (401)
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
OB-stars as extreme condition test beds [PDF]
, 2010 Massive stars are inherently extreme objects, in terms of radiation, mass loss, rotation, and sometimes also magnetic fields. Concentrating on a (personally biased) subset of processes related to pulsations, rapid rotation and its interplay with mass ...
González, Jorge G. Rivero +2 more
core +1 more source
In vitro grafting of hepatic spheroids and organoids on a microfluidic vascular bed [PDF]
, 2022 Flavio Bonanini +25 more
openalex +1 more source
HSP70 governs permeability and mechanotransduction in primary human endothelial cells
FEBS Open Bio, EarlyView.HSP70 chemical inhibition reduces endothelial cell proliferation and increases permeability, the latter supported by normal interendothelial junctional protein distribution. HSP70 also plays a role in shear stress response, a hemodynamic force naturally present in blood vessels and correlated with vessel protection.
Andrea Pinto‐Martinez +5 more
wiley +1 more source
FEATURES OF THE INFRASTRUCTURE AND FLOWS INVOLVED IN TOURISM DEVELOPMENT IN MUREŞ COUNTY [PDF]
Analele Universităţii din Oradea: Seria Geografie, 2017 Tackling the topic regarding the spatial distribution of the accommodation/lodging infrastructure of Mureş County for the entire transition period required first and foremost a quantitative analysis, with data sets from the National Institute of ...
George-Bogdan TOFAN, Adrian NIŢĂ
doaj
Cloning, expression, purification, and structural modeling of the Chandipura virus matrix protein
FEBS Open Bio, EarlyView.This research protocol offers a guide for the cloning, expression, and purification of the Chandipura virus matrix protein using E. coli. It also includes a step‐by‐step procedure for cloning, expressing, and conducting fluorescence imaging of GFP‐fused Chandipura virus matrix protein in mammalian cell lines.
Mariana Grieben
wiley +1 more source
Assessing equity in the distribution of hospital beds: evidence from northern Iran
Proceedings of Singapore Healthcare, 2019 Objective: To assess equity in the distribution of hospital beds in northern Iran. Methods: In this cross-sectional study, we investigated the degree of equity by using 2016 census data from 16 cities in Guilan province.
Javad Ebrahimzadeh +7 more
doaj +1 more source
Mesocale approach for fluidized beds [PDF]
, 2013 Fluid-particle flows are frequently encountered in industrial facilities and especially in chemical engineering processes. In this work, we focus on fluidized beds, which involve a fluid flow passing upward through a pack of particles with such a ...
Bernard, Manuel +2 more
core
FEBS Open Bio, EarlyView.Induction of diabetes in three different mouse strains uniformly resulted in an increase in TNAP activity and a reduction in pyrophosphate (PPi) in the circulation. Inhibition of TNAP restored plasma PPi. Diabetes‐induced calcification in the media layer of the aorta was detected only in the Abcc6−/− strain, which is predisposed to ectopic ...
Krisztina Fülöp +13 more
wiley +1 more source
Exploring accuracy of statistical characterization of gravel beds using Kinect device in the laboratory scale [PDF]
Journal of Hydraulic Structures, 2019 Mountainous river beds-generally consist of gravel particles that the precise description of such bed is not only important hydraulically, but also it has great environmental significance.
Hadi Bali +3 more
doaj +1 more source