Results 61 to 70 of about 1,724,338 (396)
Molecular Oncology, EarlyView.Urinary LGALS3BP is elevated in bladder cancer patients compared to healthy controls as detected by the 1959 antibody–based ELISA. The antibody shows enhanced reactivity to the high‐mannose glycosylated variant secreted by cancer cells treated with kifunensine (KIF).
Asia Pece +18 more
wiley +1 more source
Optimization of Powder Layer Density in Selective Laser Sintering [PDF]
, 1999 An important parameter for the overall quality of SLS parts is the density of powder layers before sintering. Previous studies have shownthatthe control of powder particle shape and size distribution can increase the density of non-packed powder beds ...
Egger, G. +3 more
core +1 more source
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
FEATURES OF THE INFRASTRUCTURE AND FLOWS INVOLVED IN TOURISM DEVELOPMENT IN MUREŞ COUNTY [PDF]
Analele Universităţii din Oradea: Seria Geografie, 2017 Tackling the topic regarding the spatial distribution of the accommodation/lodging infrastructure of Mureş County for the entire transition period required first and foremost a quantitative analysis, with data sets from the National Institute of ...
George-Bogdan TOFAN, Adrian NIŢĂ
doaj
Does the Use of Perennials in Flower Beds Necessarily Imply Sustainability?
Plants, 2023 Green spaces are becoming increasingly important for cities due to the growing pressures of urbanization and climate change. Along with trees, shrubs, and lawns, flower beds are an important part of urban green spaces.
Miroslav Poje +3 more
doaj +1 more source
Mesocale approach for fluidized beds [PDF]
, 2013 Fluid-particle flows are frequently encountered in industrial facilities and especially in chemical engineering processes. In this work, we focus on fluidized beds, which involve a fluid flow passing upward through a pack of particles with such a ...
Bernard, Manuel +2 more
core
Hybrid Electron Beam Powder Bed Fusion Additive Manufacturing of Ti–6Al–4V: Processing, Microstructure, and Mechanical Properties [PDF]
, 2022 Riccardo Tosi +4 more
openalex +1 more source
Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib
Molecular Oncology, EarlyView.WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute +17 more
wiley +1 more source
Assessing equity in the distribution of hospital beds: evidence from northern Iran
Proceedings of Singapore Healthcare, 2019 Objective: To assess equity in the distribution of hospital beds in northern Iran. Methods: In this cross-sectional study, we investigated the degree of equity by using 2016 census data from 16 cities in Guilan province.
Javad Ebrahimzadeh +7 more
doaj +1 more source
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source