Results 11 to 20 of about 185,151 (309)

Coupling of a Novel TIMP3 Peptide to Carboxypeptidase G2 for Pro-Drug Activation at the Tumour Site

Molecules, 2021
Broad-spectrum cytotoxic drugs have been used in cancer therapy for decades. However, their lack of specificity to cancer cells often results in serious side-effects, limiting efficacy.
Mohammed S. Aldughaim, Fatimah Alsaffar, Michael D. Barker   +2 more
doaj   +1 more source

Ice storm effects on the canopy structure of a northern hardwood forest after 8 years [PDF]

, 2009
Ice storms can cause severe damage to forest canopies, resulting in differential mortality among tree species and size classes and leading to long-lasting changes in the vertical structure and composition of the forest.
Hamburg, Steven P., Vadeboncoeur, Matthew A., Weeks, Brian C.   +2 more
core   +3 more sources

Inhibiting the P2X4 Receptor Suppresses Prostate Cancer Growth In Vitro and In Vivo, Suggesting a Potential Clinical Target

Cells, 2020
Prostate cancer (PCa) is the most frequently diagnosed cancer in men, causing considerable morbidity and mortality. The P2X4 receptor (P2X4R) is the most ubiquitously expressed P2X receptor in mammals and is positively associated with tumorigenesis in ...
Jiepei He, Yuhan Zhou, Hector M. Arredondo Carrera, Alexandria Sprules, Ramona Neagu, Sayyed Amin Zarkesh, Colby Eaton, Jian Luo, Alison Gartland, Ning Wang   +9 more
doaj   +1 more source

Low-dose Oral Thimerosal for the Treatment of Oral Herpes: Clinical Trial Results and Improved Outcome After Post-hoc Analysis

Journal of Evidence-Based Integrative Medicine, 2022
Background Thimerosal (TML) is an organomercury antimicrobial. Low doses (1/250 th of the amount in a typical vaccine dose) may promote an antiviral immune response.
Stephen W. Mamber, Thomas Hatch, Craig S. Miller, John V. Murray, Cynthia Strout, John McMichael   +5 more
doaj   +1 more source

Environmental change impacts on the C- and N-cycle of European forests: a model comparison study [Discussion paper] [PDF]

, 2012
Forests are important components of the greenhouse gas balance of Europe. There is considerable uncertainty about how predicted changes to climate and nitrogen deposition will perturb the carbon and nitrogen cycles of European forests and thereby alter ...
Butterbach-Bahl, Klaus, Cameron, David R., De Vries, Wim, Grote, Rüdiger, Haas, Edwin, Heuvelink, Gerardus Bernardus Maria, Kiese, Ralf, Kros, Johannes, Kuhnert, Matthias, Leip, Adrian, Oijen, Marcel van, Reinds, Gert Jan, Reuter, Hannes Isaak, Schelhaas, Mart Jan, Werner, Christian, Yeluripati, Jagadeesh   +15 more
core   +1 more source

TRAIL Deficient Mice Are Protected from Sugen/Hypoxia Induced Pulmonary Arterial Hypertension

Diseases, 2014
Pulmonary arterial hypertension (PAH) is a progressive lung disease diagnosed by an increase in pulmonary arterial blood pressure that is driven by a progressive vascular remodelling of small pulmonary arterioles.
Sarah H. Dawson, Nadine D. Arnold, Josephine A. Pickworth, Sheila E. Francis, Allan Lawrie   +4 more
doaj   +1 more source

Specific Targeting of PEGylated Liposomal Doxorubicin (Doxil^®) to Tumour Cells Using a Novel TIMP3 Peptide

Molecules, 2020
Doxorubicin is a cytotoxic anthracycline derivative that has been used as a chemotherapeutic in many different forms of human cancer with some success. However, doxorubicin treatment has several side-effects, the most serious of which is cardiomyopathy ...
Mohammed S. Aldughaim, Munitta Muthana, Fatimah Alsaffar, Michael D. Barker   +3 more
doaj   +1 more source

Picturing, Pledges and Other Scripted Acts: Performance (In) Art

Arts, 2023
This essay re-examines several examples of non-performance based artworks from the perspective and history of performance art. For instance, the photomontages I produced as an undergrad art student were based on repeated acts of stealing posters from ...
Dave Beech
doaj   +1 more source

Serotonin and Histamine Therapy Increases Tetanic Forces of Myoblasts, Reduces Muscle Injury, and Improves Grip Strength Performance of Dmd Mice

Dose-Response, 2015
Duchenne muscular dystrophy (DMD) is a recessive X-linked fatal disorder caused by a mutation in the dystrophin gene. Although several therapeutic approaches have been studied, none has led to substantial long-term effects in patients.
Volkan Gurel, Jeremy Lins, Kristyn Lambert, Joan Lazauski, James Spaulding, John McMichael   +5 more
doaj   +1 more source

Labour parties ideas transfer and ideological positioning : Australia and Britain compared [PDF]

, 2016
As part of this special issue examining policy transfer between the Labour Parties in Australia and Britain, this paper seeks to explore the relationship between the two on ideological positioning.
Beech, Matt, Edwards, Belinda M.
core   +1 more source