Results 181 to 190 of about 107,024 (299)

A Compound Screen Based on Isogenic hESC‐Derived β Cell Reveals an Inhibitor Targeting ZnT8‐Mediated Zinc Transportation to Protect Pancreatic β Cell from Stress‐Induced Cell Death

open access: yesAdvanced Science, EarlyView.
Pancreatic β cell loss by cellular stress contributes to diabetes pathogenesis. The study demonstrates that WFS1–ZnT8–zinc axis regulates vicious cycle of zinc transportation and cellular stress in pancreatic β cell. Based on that, the study applies a strategy for compound screening targeting ZnT8 based on human models, and identifies anisomycin, as a ...
Rui Hu   +19 more
wiley   +1 more source

Monolithic 3D Oscillatory Ising Machine Using Reconfigurable FeFET Routing for Large‐Scalability and Low‐Power Consumption

open access: yesAdvanced Science, EarlyView.
This paper introduces a novel M3D Oscillatory Ising Machine (OIM) utilizing FeFETs as in‐memory routing switches and biristors as oscillators. The system achieves precise control, scalability, and low power consumption, solving complex optimization problems like MaxCUT problem.
Joon Pyo Kim   +8 more
wiley   +1 more source

Citrullination of NF‐κB p65 by PAD2 as a Novel Therapeutic Target for Modulating Macrophage Polarization in Acute Lung Injury

open access: yesAdvanced Science, EarlyView.
Peptidyl arginine deiminase 2 (PAD2) plays a key role in regulating macrophage function in Pseudomonas aeruginosa‐induced acute lung injury (ALI). Using single‐cell RNA sequencing and proteomics, a new PAD2‐catalyzed citrullination site on NF‐κB p65 (171 Arginine), modulating macrophage polarization is identified.
Xin Yu   +11 more
wiley   +1 more source

UrBAN: Urban Beehive Acoustics and PheNotyping Dataset. [PDF]

open access: yesSci Data
Abdollahi M   +6 more
europepmc   +1 more source

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