Results 111 to 120 of about 1,858,978 (284)
The use of animal-based health and welfare parameters – what is it all about? [PDF]
, 2008 Organic farming is characterized by several goals that are expressed in daily practices and in standards. Some of the important goals for organic production systems are naturalness, harmony on all levels of production, local recycling of resources, and ...
Winckler, Christoph
core
Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source
Ecology and EvolutionLittle is known about the natural history of many Caenorhabditis nematodes, despite their relationship to the model species C. elegans. While these nematodes rely on invertebrate vectors to disperse to new habitats (phoresy), vector use for most species ...
Ryan Greenway +4 more
doaj +1 more source
Can childhood animal cruelty be learned?: examining age of onset and recurrency [PDF]
, 2014 Few studies have examined how animal cruelty can be a learned behavior. Using data collected from 257 male inmates at a Southern state medium-security prison, the current study seeks to replicate the Hensley, Tallichet and Dutkiewicz (2012) study.
Browne, John A.
core +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Satellite (IRLS) tracking of elk [PDF]
The practicability of tracking free roaming animals in natural environments by satellite systems is reported. Satellite systems combine continuous tracking with simultaneous monitoring of physiological and environmental parameters through a combination ...
Buechner, H. K.
core +1 more source
LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro
Molecular Oncology, EarlyView.Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix +13 more
wiley +1 more source
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
The Affect of Animal Gender on Fed Cattle Producer Marketing Behavior [PDF]
Weekly grid market share by volume for slaughter steers is compared to slaughter heifers. Summary statistics indicate average grid market share for steers (42%) is 27% higher than slaughter heifers (33%).
Diersen, Matthew A. +4 more
core +1 more source
Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition
Molecular Oncology, EarlyView.We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li +10 more
wiley +1 more source