Results 91 to 100 of about 1,858,978 (284)
Methods in Ecology and EvolutionBioacoustic research, vital for promoting conservation and understanding animal behaviour and ecology, faces a monumental challenge: analysing vast datasets where animal vocalizations are rare.
Julian C. Schäfer‐Zimmermann +11 more
doaj +1 more source
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Animal Spirits: Affective and Deliberative Processes in Economic Behavior [PDF]
The economic conception of human behavior assumes that a person has a single set of well-defined goals, and that the person's behavior is chosen to best achieve those goals. We develop a model in which a person's behavior is the outcome of an interaction
Loewenstein, George, O'Donoghue, Ted
core
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
The Journal of Poultry Science, 2011 It is important to quantify and estimate stressful stimulation because stress appears to limit productivity and welfare in poultry. The purpose of this study is to investigate the effect of acute isolation stress (5, 10 or 30min) on the levels of blood ...
Kouichi Yanagita +3 more
doaj +1 more source
Drivers of Resident Support for Animal Care Oriented Ballot Initiatives [PDF]
Recent high profile incidents and public debates in the United States have highlighted the increasing interest residents have regarding animal rearing and handling practices.
Tonsor, Glynn T., Wolf, Christopher A.
core +1 more source
FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source
Poultry Science: The present study aimed to provide further insight on different pecking behavior of beak-trimmed and untrimmed turkey hens in proximity to the feeding pan.
Nina Volkmann +5 more
doaj +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source