Results 71 to 80 of about 16,785,403 (406)
Genetic dissection of the neuro-glio-vascular machinery in the adult brain
Molecular Brain, 2018 The adult brain actively controls its metabolic homeostasis via the circulatory system at the blood brain barrier interface. The mechanisms underlying the functional coupling from neuron to vessel remain poorly understood.
Gregory W. Kirschen +9 more
doaj +1 more source
FEBS Letters, EarlyView.Metabolic dysfunction‐associated steatotic liver disease (MASLD) affects nearly one‐third of the global population and poses a significant risk of progression to cirrhosis or liver cancer. Here, we discuss the roles of hepatic dendritic cell subtypes in MASLD, highlighting their distinct contributions to disease initiation and progression, and their ...
Camilla Klaimi +3 more
wiley +1 more source
Sensory cues, behavior and fur-based drying in the rat wetness response
Scientific ReportsIt never rains in standard lab-confinements; thus we have limited understanding of animal reactions to water and wetness. To address this issue, we sprayed water on different body parts of rats and measured drying and fur temperature by thermal imaging ...
Augustine Triumph Attah +6 more
doaj +1 more source
Characterization of fungal carbonyl sulfide hydrolase belonging to clade D β‐carbonic anhydrase
FEBS Letters, EarlyView.Here, we performed a functional analysis of the fungal enzymes belonging to clade D of the β‐class carbonic anhydrase family (β‐D‐CA). The β‐D‐CAs in the basidiomycete Gloeophyllum trabeum and the ascomycete Trichoderma harzianum showed very low activity in the hydration of CO2 but exhibited high activity in the hydrolysis of carbonyl sulfide (COS ...
Ryuka Iizuka +6 more
wiley +1 more source
FEBS Letters, EarlyView.In modular polyketide synthases, the dehydratase (DH) domain catalyzes the dehydration reaction of the β‐hydroxyacyl unit attached to the cognate acyl carrier protein (ACP) domain. However, it is unclear how DH interacts with ACP during the reaction. In this study, we identified DH–ACP interface residues, providing the first detailed insights into DH ...
Kaede Kotagiri +8 more
wiley +1 more source
FEBS Letters, EarlyView.Low‐density lipoprotein receptor‐related protein 6 (LRP6) is a key receptor for the Wnt antagonist Dickkopf1 (DKK1). DKK1 protein expression is induced in a bleomycin (BLM)‐induced lung injury model. We show that DKK1 induces proinflammatory and profibrotic genes in lung fibroblasts.
Eun‐Ah Sung +6 more
wiley +1 more source
A Grounded Theory on Helping Behavior and Its Shaping Factors
Grounded Theory Review: An International Journal, 2006 In social psychology, the attribution model of helping behavior suggests that beliefs of the helping target’s responsibility for the need for help evoke affective motivators such as feelings of pity, sympathy, or anger.
A Grounded Theory on Helping Behavior and Its Shaping Factors
doaj
Quantitative results for the Fleming-Viot particle system in discrete space [PDF]
, 2013 We show, for a class of discrete Fleming-Viot type particle systems, that the convergence to the equilibrium is exponential for a suitable Wassertein coupling distance.
Bertrand Cloez +2 more
core +2 more sources
Characteristics of the Kelch domain containing (KLHDC) subfamily and relationships with diseases
FEBS Letters, EarlyView.The Kelch protein superfamily includes 63 members, with the KLHDC subfamily having 10 proteins. While their functions are not fully understood, recent advances in KLHDC2's structure and role in protein degradation have highlighted its potential for drug development, especially in PROTAC therapies.
Courtney Pilcher +6 more
wiley +1 more source
Recommender Transformers with Behavior Pathways [PDF]
arXiv, 2022 Sequential recommendation requires the recommender to capture the evolving behavior characteristics from logged user behavior data for accurate recommendations. However, user behavior sequences are viewed as a script with multiple ongoing threads intertwined.
arxiv