Results 111 to 120 of about 116,808 (300)

Systematic Irrationality and the Emergence of Behavioral Economics

Journal of Interdisciplinary History of Ideas, 2023
Journal of Interdisciplinary History of Ideas, V. 11 N.
openaire   +2 more sources

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Exploring sustainable urban mobility in Africa-and-MENA universities towards intersectional future research

Transportation Research Interdisciplinary Perspectives
As university campuses in Africa and the MENA region represent key traffic hubs in their cities, this paper develops a Systematic Literature Review (SLR) to conceptualize a “framework of action” for intersectional sustainable urban mobility.
Momen El-Husseiny, Islam Mashaly, Nouran Azouz, Nourhan Sakr, Karim Seddik, Samer Atallah   +5 more
doaj   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Merger Response of Halo Anisotropy Properties

The Astrophysical Journal
Anisotropy properties—halo spin, shape, position offset, velocity offset, and orientation—are an important family of dark matter halo properties that indicate the level of directional variation of the internal structures of halos.
Kuan Wang, Philip Mansfield, Dhayaa Anbajagane, Camille Avestruz   +3 more
doaj   +1 more source

The Reaction 7Li(pi+,pi-)7B and its Implications for 7B

, 1998
The reaction 7Li(pi+,pi-)7B has been measured at incident pion energies of 30-90 MeV. 7Li constitutes the lightest target nucleus, where the pionic charge exchange may proceed as a binary reaction to a discrete final state.
A. Denig, D. Schapler, G.J. Wagner, Gibbs, H. Clement, J. Gräter, J. Pätzold, K. Föhl, M. Schepkin, R. Bilger, R. Meier, W. Kluge   +11 more
core   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Forward-rapidity azimuthal and radial flow of identified particles for $\sqrt{s_{NN}}$ = 200 GeV Au+Au collisions

, 2009
A strong azimuthal flow signature at RHIC suggests rapid system equilibration leading to an almost perfect fluid state. The longitudinal extent of the flow behavior depends on how this state is formed and can be studied by measuring the pseudorapidity ...
Adamczyk, Back, Heiselber, Hirano, Hirano, Poskanzer, S.J. Sanders   +6 more
core   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source