Results 91 to 100 of about 1,763,020 (300)

Gut microbiota diversity is prognostic in metastatic hormone receptor‐positive breast cancer patients receiving chemotherapy and immunotherapy

Molecular Oncology, EarlyView.
In this exploratory study, we investigated the relationship between the gut microbiota and outcome in patients with metastatic hormone receptor‐positive breast cancer, treated in a randomized clinical trial with chemotherapy alone or chemotherapy in combination with immune checkpoint blockade.
Andreas Ullern, Kristian Holm, Nikolai Kragøe Andresen, Andreas Hagen Røssevold, Corinna Bang, Bjørn Naume, Johannes R. Hov, Jon Amund Kyte   +7 more
wiley   +1 more source

Expiratory Musculature Targeted Resistance Training Modulates Neural Connections During Swallowing Tasks: Preliminary fMRI Evidence

Neural Plasticity
Conclusion: Our study’s results provide preliminary evidence that EMST can modulate neural networks associated with swallowing. We speculate that enhanced sensorimotor excitability and cortical representation, motor learning, and improved cognitive ...
Rahul Krishnamurthy, Douglas H. Schultz, Yingying Wang, Steven M. Barlow, Angela M. Dietsch   +4 more
doaj   +1 more source

The value of consciousness coaching in Parkinson’s disease: Experiences and possible impact of holistic coaching

Clinical Parkinsonism & Related Disorders
Background: People with a chronic condition such as Parkinson’s disease (PD) struggle with acceptance and finding meaning in life. Consciousness coaching could be a valuable addition in addressing these issues.
Lousanne E.J. Tangelder, Ana L. Silva de Lima, Arjonne Laar, Nienke M. de Vries   +3 more
doaj   +1 more source

An Empirical Examination of Symptom Substitution Associated with Behavior Therapy for Tourette\u27s Disorder [PDF]

, 2016
Over the past six decades, behavior therapy has been a major contributor to the development of evidence-based psychotherapy treatments. However, a long-standing concern with behavior therapy among many nonbehavioral clinicians has been the potential risk
Hatch, John P., McGuire, Joseph F., Peterson, Alan L., Piacentini, John, Scahill, Lawrence, Villarreal, Robert, Walkup, John T., Wilhelm, Sabine, Woods, Douglas W.   +8 more
core   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Screening for Significant Behavior Problems in Diverse Young Children Living in Poverty [PDF]

, 2016
The development and use of first line screening instruments is an essential first step in assessing behavior disorders in very young children. The Early Childhood Behavior Screen (ECBS) is a parent-report measure for behavior disorders and is normed on ...
Fox, Robert A., Harris, Sara E., Holtz, Casey A.   +2 more
core   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

A generalizable and open-source algorithm for real-life monitoring of tremor in Parkinson’s disease

npj Parkinson's Disease
Wearable sensors can objectively and continuously monitor daily-life tremor in Parkinson’s Disease (PD). We developed an open-source algorithm for real-life monitoring of PD tremor which achieves generalizable performance across different wrist-worn ...
Nienke A. Timmermans, Roberta Terranova, Diogo C. Soriano, Hayriye Cagnan, Yordan P. Raykov, Ioan Gabriel Bucur, Bastiaan R. Bloem, Rick C. Helmich, Luc J. W. Evers   +8 more
doaj   +1 more source

Head-Up Tilt Sleeping to Treat Orthostatic Intolerance in a Patient with Advanced Parkinson’s Disease: A Case Report

Case Reports in Neurology
Introduction: Orthostatic hypotension is common in people with Parkinson’s disease (PD) due to autonomic dysfunction and medication use and can have a significant negative impact on quality of life.
Amber H. van der Stam, Sharon Shmuely, Nienke M. de Vries, Roland D. Thijs, Mirjam van Kesteren-Biegstraaten, Bastiaan R. Bloem   +5 more
doaj   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source