Results 81 to 90 of about 1,763,020 (300)
FEBS Letters, EarlyView.The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li +2 more
wiley +1 more source
Beyond the DSM-IV: Assumptions, Alternatives, and Alterations [PDF]
, 2006 Current diagnostic processes reflect the limitations and utility of the framework of the Diagnostic and Statistical Manual of Mental Disorders (4th ed.; DSM-IV; American Psychiatric Association, 1994).
Edwards, Lisa +6 more
core +1 more source
FEBS Letters, EarlyView.We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee +3 more
wiley +1 more source
Structural biology of ferritin nanocages
FEBS Letters, EarlyView.Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley +1 more source
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
Indicators of Emotional and Behavioral Problems in Adolescents: Evaluation among Multiple Informants
Paidéia (Ribeirão Preto), 2018 The prevalence rates of emotional and behavioral problems in adolescence suggest that their identification through different informants is relevant for the treatment and prevention of clinical conditions.
Bruna Mainardi Rosso Borba +1 more
doaj +1 more source
Molecular Oncology, EarlyView.AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou +5 more
wiley +1 more source
It is time to share Alzheimer biomarker results in dementia with Lewy bodies
Alzheimer’s & Dementia: Diagnosis, Assessment & Disease MonitoringThere are increasing calls for sharing individual biomarker results with participants in dementia research. No studies investigate returning Alzheimer's disease (AD) biomarker results to individuals with syndromic dementia with Lewy bodies (DLB) even ...
Melissa J. Armstrong +2 more
doaj +1 more source
Asuhan Keperawatan Jiwa Pada Ny. W Dengan Perilaku Kekerasan Diruang Srikandi Rumah Sakit Jiwa Daerah Surakarta [PDF]
, 2015 Background:Mental health is a situation where a person who is free from mental disorders, and have a positive attitude to describe the maturity and personality.
, Arif Widodo, A.Kep., M.Kes +1 more
core
Hole Localization in One-Dimensional Doped Anderson-Hubbard Model
, 2008 We study the interplay of disorder and correlation in the one-dimensional hole-doped Hubbard-model with disorder (Anderson-Hubbard model) by using the density-matrix renormalization group method.
M. MACHIDA +4 more
core +1 more source