Results 101 to 110 of about 1,852,959 (299)
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
Prediction of composite thermal behavior made simple [PDF]
A convenient procedure is described to determine the thermal behavior (thermal expansion coefficients and thermal stresses) of angleplied fiber composites using a pocket calculator. The procedure consists of equations and appropriate graphs for various (
Chamis, C. C.
core +1 more source
Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition
Molecular Oncology, EarlyView.We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li +10 more
wiley +1 more source
Controlling and Predicting Unpredictable Behavior [PDF]
The Behavior Analyst, 2014 Behaving predictably can be advantageous in some situations, but unpredictability can also be advantageous in some competitive situations like sports, games, and war. Can, however, unpredictable behavior be conditioned? If a contingency of reinforcement based upon the predictability of behavior generates unpredictable responding, is it possible to ...
openaire +2 more sources
Monte Carlo simulation by computer for life-cycle costing [PDF]
, 1969 Prediction of behavior and support requirements during the entire life cycle of a system enables accurate cost estimates by using the Monte Carlo simulation by computer.
Gralow, F. H., Larson, W. J.
core +1 more source
Molecular Oncology, EarlyView.Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff +11 more
wiley +1 more source
Molecular Oncology, EarlyView.We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala +15 more
wiley +1 more source
Journal of Marine Science and EngineeringThe prediction of drag anchor trajectory is key for the anchor design. The yield envelope method based on anchor behavior under combined loadings provided an alternative method for the prediction of anchor trajectory.
Xiaoni Wu +5 more
doaj +1 more source
Automated drowsiness detection for improved driving safety [PDF]
, 2008 Several approaches were proposed for the detection and prediction of drowsiness. The approaches can be categorized as estimating the fitness of duty, modeling the sleep-wake rhythms, measuring the vehicle based performance and online operator monitoring ...
Bartlett, Marian +7 more
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