Results 171 to 180 of about 1,419,032 (336)

A nucleotide‐independent, pan‐RAS‐targeted DARPin elicits anti‐tumor activity in a multimodal manner

Molecular Oncology, EarlyView.
We report a Designed Ankyrin Repeat Protein that binds and inhibits RAS proteins, which serve as central cell signaling hubs and are essential for the progression of many cancers. Its unique feature is that it does not discriminate between different RAS isoforms or mutations and is capable of binding to RAS in both its active (GTP‐bound) and inactive ...
Jonas N. Kapp, Wouter P. R. Verdurmen, Jonas V. Schaefer, Kari Kopra, Gabriela Nagy‐Davidescu, Elodie Richard, Marie‐Julie Nokin, Patrick Ernst, Rastislav Tamaskovic, Martin Schwill, Ralph Degen, Claudia Scholl, David Santamaria, Andreas Plückthun   +13 more
wiley   +1 more source

Cognitive‐behavioral group therapy versus phenelzine in social phobia: Long term outcome

, 1999
Michael R. Liebowitz, Richard G. Heimberg, Franklin R. Schneier, Debra A. Hope, Sharon Davies, Craig S. Holt, Deborah Goetz, Harlan R. Juster, Shu‐Hsing Lin, Monroe A. Bruch, Randall D. Marshall, Donald F. Klein   +11 more
openalex   +1 more source

Therapeutic applications of a novel humanized monoclonal antibody targeting chemokine receptor CCR9 in pancreatic cancer

Molecular Oncology, EarlyView.
C–C chemokine receptor type 9 (CCR9) is an immune checkpoint in pancreatic ductal adenocarcinoma (PDAC). Novel anti‐CCR9 antibody SRB2 was evaluated in combination with cytotoxic chemotherapy in PDAC cells, patient‐derived organoids, patient‐derived xenografts, and humanized mouse models.
Hannah G. McDonald, Anna M. Reagan, Charles J. Bailey, Mei Gao, Muqiang Gao, Angelica L. Solomon, Michael J. Cavnar, Prakash K. Pandalai, Mautin T. Barry‐Hundeyin, Megan M. Harper, Justin A. Rueckert, Ángela Turrero, Araceli Tobio, Anxo Vidal, Daniel Roca‐Lema, Elia Álvarez‐Coiradas, Pablo Garrido, Laureano Simón, Joseph Kim   +18 more
wiley   +1 more source

Virtual-reality cognitive behavior therapy versus cognitive behavior therapy for paranoid ideation: A pragmatic, single-blind, multicenter randomized clinical superiority trial. [PDF]

Psychol Med
van der Stouwe ECD, Geraets CNW, Berkhof M, Hidding M, van Amstel S, van den Berg D, van Grunsven R, de Jager J, Kooijmans E, Sageot M, Staring ABP, Vos M, Zandee CER, Veling W.   +13 more
europepmc   +1 more source

Cognitive behavior therapy for chronic fatigue syndrome

, 1995
Trudie Chalder, Alicia Deale, Simon Wessely   +2 more
openalex   +1 more source

BMP antagonist CHRDL2 enhances the cancer stem‐cell phenotype and increases chemotherapy resistance in colorectal cancer

Molecular Oncology, EarlyView.
Overexpression of CHRDL2 in colon cancer cells makes them more stem‐like and resistant to chemo‐ and radiotherapy. CHRDL2‐high cells have upregulation of the WNT pathway, genes involved in the DNA damage response (DDR) pathway and epithelial‐to‐mesenchymal transition (EMT). This leads to quicker repair of damaged DNA and more cell migration.
Eloise Clarkson, Annabelle Lewis
wiley   +1 more source

Meta-anlaysis of Internet-based Behavior Therapy for Tic Disorder. [PDF]

Clin Psychopharmacol Neurosci
Jo YD, Kim DJ, Hwang KS, Jung CG, Lee SW, Lee DH, Jung SI, Yoon SH, Lee SY, Yang CM.   +9 more
europepmc   +1 more source

Melatonin therapy for REM sleep behavior disorder [PDF]

, 2001
Noboru Takeuchi, Naohisa Uchimura, Yuji Hashizume, Masaki Mukai, Y Etoh, Katsuyasu YAMAMOTO, Tatayu Kotorii, H Ohshima, Masachika Ohshima, Hisao Maeda   +9 more
openalex   +1 more source

Simultaneous inhibition of TRIM24 and TRIM28 sensitises prostate cancer cells to antiandrogen therapy, decreasing VEGF signalling and angiogenesis

Molecular Oncology, EarlyView.
TRIM24 and TRIM28 are androgen receptor (AR) coregulators which exhibit increased expression with cancer progression. Both TRIM24 and TRIM28 combine to influence the response of castrate‐resistant prostate cancer (CRPC) cells to AR inhibitors by mediating AR signalling, regulation of MYC and upregulating VEGF to promote angiogenesis. Castrate‐resistant
Damien A. Leach, Nilesh Chatterjee, Kellie Spahr, Gilberto Serrano de Almeida, Anabel Varela‐Carver, Taimur T. Shah, Mathias Winkler, Hashim U. Ahmed, Charlotte L. Bevan   +8 more
wiley   +1 more source

Rational Emotive Behavior Therapy for exercise: examining self-determined motivation, alongside readiness, confidence, and motivation to exercise. [PDF]

Front Psychol
Turner MJ, Frost N, Outar L, O'Connor H, Tóth R, Tóth L, Chadha N, Wood AG.   +7 more
europepmc   +1 more source