Results 221 to 230 of about 1,703,732 (307)

Evaluation of dialectical behavior therapy - skills training for emotional problem solving for adolescents (DBT STEPS-A) in Aotearoa New Zealand: Protocol of a mixed-methods evaluation. [PDF]

BMC Psychol
Donkin L, Thakral P, Hindle S, Kercher A.   +3 more
europepmc   +1 more source

The role of lipid metabolism in neuronal senescence

FEBS Open Bio, EarlyView.
Disrupted lipid metabolism, through alterations in lipid species or lipid droplet accumulation, can drive neuronal senescence. However, lipid dyshomeostasis can also occur alongside neuronal senescence, further amplifying tissue damage. Delineating how lipid‐induced senescence emerges in neurons and glial cells, and how it contributes to ageing and ...
Dikaia Tsagkari, Eleftheria Panagiotidou, Nektarios Tavernarakis   +2 more
wiley   +1 more source

Microglial dynamics and ferroptosis induction in human iPSC‐derived neuron–astrocyte–microglia tri‐cultures

FEBS Open Bio, EarlyView.
A tri‐culture of iPSC‐derived neurons, astrocytes, and microglia treated with ferroptosis inducers as an Induced ferroptosis model was characterized by scRNA‐seq, cell survival, and cytokine release assays. This analysis revealed diverse microglial transcriptomic changes, indicating that the system captures key aspects of the complex cellular ...
Hongmei Lisa Li, Hiroko Ohmiya, Sou Sakamoto, Masato Yugami, Akiko Oki, Makoto Furusawa, Yan Ling   +6 more
wiley   +1 more source

Cognitive Behavior Therapy for Mental Disorders in Adults: A Unified Series of Meta-Analyses.

JAMA Psychiatry
Cuijpers P, Harrer M, Miguel C, Ciharova M, Papola D, Basic D, Botella C, Cristea I, de Ponti N, Donker T, Driessen E, Franco P, Gómez-Gómez I, Hamblen J, Jiménez-Orenga N, Karyotaki E, Keshen A, Linardon J, Motrico E, Matbouriahi M, Panagiotopoulou OM, Pfund RA, Plessen CY, Riper H, Schnurr PP, Sijbrandij M, Toffolo MBJ, Tong L, van Ballegooijen W, van der Ven E, van Straten A, Wang Y, Furukawa TA.   +32 more
europepmc   +1 more source

Relationships Among Patients' Interpersonal Behaviors in Sessions, Therapist Competence, and the Therapeutic Alliance in Cognitive Behavior Therapy: A Cross-Lagged Panel Analysis. [PDF]

J Clin Psychol
Maaß U, Witthöft M, Junga YM, Hahn D, Weck F.   +4 more
europepmc   +1 more source

BMI‐1 modulation and trafficking during M phase in diffuse intrinsic pontine glioma

FEBS Open Bio, EarlyView.
The schematic illustrates BMI‐1 phosphorylation during M phase, which triggers its translocation from the nucleus to the cytoplasm. In cycling cells, BMI‐1 functions within the PRC1 complex to mediate H2A K119 monoubiquitination. Following PTC596‐induced M phase arrest, phosphorylated BMI‐1 dissociates from PRC1 and is exported to the cytoplasm via its
Banlanjo Umaru, Deepak Kumar Mishra, Shiva Senthil Kumar, Hao‐Han Pang, Brendan Devine, Komal Khan, Rachid Drissi   +6 more
wiley   +1 more source

Personalized Transdiagnostic Cognitive Behavior Therapy With Midtreatment Stepped Care to Improve Mental Health Among University Students in Sweden: Feasibility Study for a Randomized Controlled Trial. [PDF]

JMIR Form Res
Topooco N, Lindner P, Andersson C, Lindfors P, Molander O, Kraepelien M, Sundström C, Vlaescu G, Andersson G, Bendtsen M, Berman AH.   +10 more
europepmc   +1 more source

The cooperative regulation of miR‐221 by APE1 and AUF1 impacts p27Kip1 defining a miR signature relevant for cervical cancer

FEBS Open Bio, EarlyView.
A regulatory axis involving APE1, AUF1, and miR‐221 is proposed. Pri‐miR‐221 is processed by DROSHA and DICER to generate mature miR‐221, which targets p27Kip1 mRNA. APE1 and AUF1 compete for pre‐miR‐221 binding. Reduced APE1/AUF1 levels impair miR‐221 biogenesis, decrease p27Kip1 mRNA degradation, and promote cell cycle progression, chemoresistance ...
Matilde Clarissa Malfatti, Nicolò Gualandi, Gianluca Tell, Giulia Antoniali   +3 more
wiley   +1 more source

Study protocol for a parallel-group randomized controlled trial of internet-delivered behavior therapy for adults with Tourette syndrome. [PDF]

Front Digit Health
Sannemalm M, Lybert N, Gunnarsson L, Andrén P, Kraepelien M, Bragesjö M, Fondberg R, Ivanov VZ, Mataix-Cols D, Fernández de la Cruz L, Andersson E, Rück C, Ivanova E.   +12 more
europepmc   +1 more source

Dapagliflozin prevents methylglyoxal‐induced retinal cell death in ARPE‐19 cells

FEBS Open Bio, EarlyView.
Diabetic macular oedema is a diabetes complication of the eye, which may lead to permanent blindness. ARPE‐19 are human retinal cells used to study retinal diseases and potential therapeutics. Methylglyoxal is a compound increased in uncontrolled diabetes due to elevated blood glucose.
Naina Trivedi, Zainab Quraishi, Shima Khezri Azizi Far, Madaleine Ward, Aidan Conway, Reem Abdulredha, Eman Mshari, Yousif A. Shamsaldeen   +7 more
wiley   +1 more source