Results 121 to 130 of about 1,120,327 (255)

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

open access: yesMolecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka   +9 more
wiley   +1 more source

The landscape of open science in behavioral addiction research: Current practices and future directions. [PDF]

open access: yesJ Behav Addict, 2023
Eben C   +12 more
europepmc   +1 more source

Excessive computer game playing : evidence for addiction and aggression? [PDF]

open access: yes, 2007
Computer games have become an ever-increasing part of many adolescents’ day-to-day lives. Coupled with this phenomenon, reports of excessive gaming (computer game playing) denominated as “computer/video game addiction” have been discussed in the popular ...
Griffiths, MD   +2 more
core  

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

open access: yesMolecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu   +13 more
wiley   +1 more source

Social Media Addiction as an Emerging Clinical Disorder: A Psychological-Behavioral Analytical Approach

open access: yesAl-Jamie Journal in Psychological Studies and Educational Sciences
social media has become so widespread that it is now an integral part of daily life; however, in some cases, this intensive use can develop into a compulsive behavioral pattern with addictive characteristics.
لبنى سفاري, كميلة سيدر
doaj   +1 more source

Behavioral Economics and Health Economics [PDF]

open access: yes
The health sector is filled with institutions and decision-making circumstances that create friction in markets and cognitive errors by decision makers.
Richard G. Frank
core  

Cancer‐associated mutations in endometriosis reframe a benign disease through molecular oncology

open access: yesMolecular Oncology, EarlyView.
This review aims to comprehensively analyse cancer‐associated somatic mutations (CAMs) present in endometriotic lesions, emphasizing their biological roles, spatial distribution and implications for translational applications in medicine. By contextualizing a benign state within a genomic framework, this analysis seeks to establish its value as a ...
Clarissa Mujacic   +15 more
wiley   +1 more source

British journal of addiction.

open access: yes, 1903
Contains papers read at the quarterly meetings of the society, and extracts from the discussions following them with other communications dealing with alcohol and alcoholism.Title varies slightly.Title from cover.None published July-Dec.
Society for the Study of Addiction to Alcohol and Other Drugs.   +1 more
core  

Preoperative circulating tumor cells integrated with imaging analysis for prognostic evaluation in head and neck squamous cell carcinoma

open access: yesMolecular Oncology, EarlyView.
Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach   +9 more
wiley   +1 more source

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