Results 1 to 10 of about 593,000 (263)

Parental Burden and Quality of Life in 5q-SMA Diagnosed by Newborn Screening

Children, 2022
The aim of this study was to assess the psychosocial burden in parents of children with spinal muscular atrophy (SMA), detected by newborn screening (NBS), for which first pilot projects started in January 2018 in Germany. The survey, performed 1–2 years
Heike Kölbel, Laura Modler, Astrid Blaschek, Ulrike Schara-Schmidt, Katharina Vill, Oliver Schwartz, Wolfgang Müller-Felber   +6 more
doaj   +1 more source

A zinc-finger fusion protein refines Gal4-defined neural circuits

Molecular Brain, 2018
The analysis of behavior requires that the underlying neuronal circuits are identified and genetically isolated. In several major model species—most notably Drosophila—neurogeneticists identify and isolate neural circuits with a binary heterologous ...
Shamprasad Varija Raghu, Farhan Mohammad, Jia Yi Chua, Joanne Shi Woon Lam, Mavis Loberas, Sadhna Sahani, Claudia S. Barros, Adam Claridge-Chang   +7 more
doaj   +1 more source

Microproteins Simba1 and Simba2 activate Wingless signaling during the reactivation of neural stem cells in Drosophila

Nature Communications
The ability of neural stem cells (NSCs) to switch between quiescent and proliferative states is fundamental for adult neurogenesis and regeneration. Microproteins or short open reading frame (sORF)-encoded peptides (SEPs), are highly abundant yet largely
Jiaen Lin, Qiannan Deng, Yang Gao, Ye Sing Tan, Zheng Zhong, Lay Keng Angie Tan, Boon Ooi Patrick Tan, David M. Virshup, Justin A. Bosch, Norbert Perrimon, Hongyan Wang   +10 more
doaj   +1 more source

Effects of Gender and Social Network Use on High School Students’ Emotional Well-Being during COVID-19

Psychiatry International
Various studies conducted during the COVID-19 pandemic have confirmed changes in online behaviour, with young people increasingly using social networks.
Sabina Mandić, Neven Ricijaš, Dora Dodig Hundrić   +2 more
doaj   +1 more source

Autism-like behaviours and enhanced memory formation and synaptic plasticity in Lrfn2/SALM1-deficient mice

Nature Communications, 2017
Lrfn2/SALM1 is a synaptic adhesion molecule, and is known to interact with PSD-95. Here the authors show that Lrfn2 regulates excitatory synapse maturation and maintenance, and that Lrfn2 knockout mice exhibit autism-like behaviours as well as enhanced ...
Naoko Morimura, Hiroki Yasuda, Kazuhiko Yamaguchi, Kei-ichi Katayama, Minoru Hatayama, Naoko H. Tomioka, Maya Odagawa, Akiko Kamiya, Yoshimi Iwayama, Motoko Maekawa, Kazuhiko Nakamura, Hideo Matsuzaki, Masatsugu Tsujii, Kazuyuki Yamada, Takeo Yoshikawa, Jun Aruga   +15 more
doaj   +1 more source

Role of endogenous ouabain in the etiology of bipolar disorder

International Journal of Bipolar Disorders, 2021
Background Bipolar disorder is a severe psychiatric illness with poor prognosis and problematic and suboptimal treatments. Understanding the pathoetiologic mechanisms may improve treatment and outcomes. Discussion Dysregulation of cationic homeostasis is
Rif S. El-Mallakh, Yonglin Gao, Pan You
doaj   +1 more source

Processing speed — A potential candidate cognitive endophenotype for bipolar disorder

Journal of Affective Disorders Reports, 2023
Background: Bipolar disorder (BD) is a chronic multifactorial disorder that presents with cognitive impairment as one of its main features, in patients as well as in their first-degree relatives.
Mirona Letitia Dobri, Taya Prince, Alexandre Paim Diaz, Giovana B. Zunta-Soares, Sudhakar Selvaraj, Rodrigo Machado-Vieira, Thomas D. Meyer, Marsal Sanches, Jair C. Soares   +8 more
doaj   +1 more source

Thalamic alexia with agraphia

Neurology International, 2012
Alexia with agraphia is defined as an acquired impairment affecting reading and writing ability. It can be associated with aphasia, but can also occur as an isolated entity. This impairment has classically been associated with a left angular gyrus lesion
Fábio Henrique de Gobbi Porto, Maria Isabel d’Ávila Freitas, Maira Okada de Oliveira, Leandro Tavares Lucato, Marco Orsini, Sara Lúcia Silveira de Menezes, Regina Miksian Magaldi, Cláudia Sellitto Porto, Sonia Maria Dozzi Brucki, Ricardo Nitrini   +9 more
doaj   +1 more source

Integrative Modeling of Individual Differences Recognizing Speech in Noise by Hearing-Impaired Adults

Trends in Hearing
Difficulty recognizing speech in noise is a common complaint among those with sensorineural hearing loss. Yet the degree of difficulty differs widely among individuals, often unrelated to the clinical gold standard for evaluating hearing, the pure-tone ...
Robert A Lutfi, Lindsey Kummerer, Jungmee Lee, Varsha Rallapalli   +3 more
doaj   +1 more source

Balance-energy of resting state network in obsessive-compulsive disorder

Scientific Reports, 2023
Stability of the brain functional network is directly linked to organization of synchronous and anti-synchronous activities. Nevertheless, impact of arrangement of positive and negative links called links topology requires to be well understood.
Alireza Talesh, Asghar Zarei, Saeid Yazdi-Ravandi, Ali Ghaleiha, Farshid Shamsaei, Nasrin Matinnia, Jamal Shams, Mohammad Ahmadpanah, Zahra Taslimi, Abbas Moghimbeigi, Reza Khosrowabadi   +10 more
doaj   +1 more source