Results 71 to 80 of about 2,215,981 (303)

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

open access: yesFEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta   +3 more
wiley   +1 more source

Impact of Postpartum Factors and Continued Stressors on Toddler Behavioral Inhibition [PDF]

open access: yes, 2023
The postpartum period is often characterized by increased stressors for a mother. Previous research has shown how maternal factors may impact a child’s attachment and behavioral development. This study investigates how maternal factors (parenting stress,
Frisch, Caroline
core   +1 more source

A cross-cultural study of behavioral inhibition in toddlers: East-West-North-South

open access: yes, 2021
The prevalence of behavioral inhibition in toddlers was examined in five cultures. Participants in this study included 110 Australian, 108 Canadian, 151 Chinese, 104 Italian, and 113 South Korean toddlers and their mothers who were observed during a ...
도현심, 박성연
core   +2 more sources

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

open access: yesFEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas   +4 more
wiley   +1 more source

Behavioral inhibition in children with learning disabilities [PDF]

open access: yesResearch in Developmental Disabilities, 2013
Children with reading disabilities (RD, n=17), mathematical disabilities (MD, n=22), combined reading and mathematical disabilities (RD+MD, n=28) and control peers (n=45) were tested on behavioral inhibition with a Go/no-go task in a picture, letter and digit-modality.
De Weerdt, Frauke   +2 more
openaire   +2 more sources

Liver organoids: modelling complexity in homeostasis and disease

open access: yesFEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Direct and Indirect Relationships Between Personality Characteristics, Humor Styles and University Adjustment: The Mediating Role of Humor Styles

open access: yesPsikoloji Çalışmaları, 2020
University adjustment is one of the most common life challenges that freshman encounter. There may be several individual differences that can either positively or negatively affect the adjustment process.
Ömer Taha Sözer   +4 more
doaj   +1 more source

Optogenetic inhibition of behavior with anion channelrhodopsins [PDF]

open access: yesNature Methods, 2017
Optogenetics uses light exposure to manipulate physiology in genetically modified organisms. Abundant tools for optogenetic excitation are available, but the limitations of current optogenetic inhibitors present an obstacle to demonstrating the necessity of neuronal circuits.
Farhan Mohammad   +7 more
openaire   +2 more sources

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

open access: yesFEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri   +5 more
wiley   +1 more source

Beyond Behavioral Inhibition: A Computer Avatar Task Designed to Assess Behavioral Inhibition Extends to Harm Avoidance

open access: yesFrontiers in Psychology, 2017
Personality factors such as behavioral inhibition (BI), a temperamental tendency for avoidance in the face of unfamiliar situations, have been identified as risk factors for anxiety disorders.
Michael Todd Allen   +3 more
doaj   +1 more source

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