Results 131 to 140 of about 618,506 (310)

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

open access: yesMolecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric   +10 more
wiley   +1 more source

Determinant of Taxpayer's Behavioral Intention to Use ­E­System in Taxation [PDF]

open access: yes, 2017
Determinant of Taxpayer's Behavioral Intention to Use ­E­System in Taxation. The purpose ofthis research is to examine the effect of attitude, subjective norms, perceived behavior control,perceived usefulness, perceived ease of use, self-efficacy and ...
Roekhudin, R. (Roekhudin)   +2 more
core  

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

open access: yesMolecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni   +11 more
wiley   +1 more source

Analisis Penerimaan Penerapan PARIS (Parking Information System) dengan Metode Technology Acceptance Model (TAM) pada Area Parkir STIKOM Surabaya [PDF]

open access: yes, 2016
This study aims to determine the perception of convenience and perceived benefit associated with the use of PARIS (Parking Information System) by adopting a model TAM 1 (Technology Acceptance Model), which consists of several constructs that perceived ...
Erstiawan, M. S. (Martinus)   +2 more
core   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

open access: yesMolecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova   +14 more
wiley   +1 more source

Faktor yang Berpengaruh terhadap Kepuasan Konsumen dan Behavioral Intention dengan Perceived Value sebagai Variabel Moderasi [PDF]

open access: yes, 2012
It has often been argued that customer satisfaction can contri-bute significantly to a company's success in a variety of ways. This study aims to analyze effect of three determinants of quality dimen-sions (product, service, and physical environment) to ...
Untung Sriwidodo, Ernawati &
core  

Unveiling the Multidimensional Nature of the Intention–Behavior Gap

open access: yesEuropean Journal of Health Psychology
Abstract: The intention-behavior gap (IBG) is a central challenge in health psychology, with significant implications for behavior change and health promotion. Prevailing approaches to IBG assessment involve quantifying it as either the proportion of unexplained variance in behavior attributable to intention or the ratio of unsuccessful intenders to ...
Darko Jekauc   +3 more
openaire   +4 more sources

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

open access: yesMolecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

NKCC1: A key regulator of glioblastoma progression

open access: yesMolecular Oncology, EarlyView.
Glioblastoma (GBM) progression is driven by disrupted chloride cotransporter homeostasis. NKCC1 is highly expressed in stem‐like, astrocytic, and progenitor cells, correlating with earlier recurrence, while overall survival remains unaffected. NKCC1 serves as a prognostic marker and potential therapeutic target, linking chloride transporter imbalance ...
Anja Thomsen   +5 more
wiley   +1 more source

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