Results 61 to 70 of about 636,063 (259)

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Salmonella lipopolysaccharide‐containing supported lipid bilayers as platforms to study bacteriophage interactions

FEBS Letters, EarlyView.
We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace, Alyssa Borges, Charles Arnaud, Tove Karlsson, Nina K. Bröker, Stefanie Barbirz, Marta Bally   +6 more
wiley   +1 more source

Sleep Disturbances in Chinese Children with Epilepsy: Associations with Behavioral Problems and Quality of Life

Nature and Science of Sleep, 2022
Fen Zhao,1,* Xiaoning Sun,2,* Yingyan Wang,1 Yunqing Zhou,1 Yingzhong He,1 Cuijin Wang,1 Feng Han,1 Jie Liu,1 Shao-Yu Tsai,3 Guanghai Wang,2 Jiwen Wang1 1Department of Pediatric Neurology, Shanghai Children’s Medical Center, School of Medicine ...
Zhao F, Sun X, Wang Y, Zhou Y, He Y, Wang C, Han F, Liu J, Tsai SY, Wang G, Wang J   +10 more
doaj  

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

Embedding a Psychologist Into Primary Care Increases Access to Behavioral Health Services

Journal of Primary Care & Community Health, 2015
Background: Patients commonly report psychological issues during primary care visits; however, few patients will follow through with a referral for behavioral health services at an outside facility.
Lisa Renee Miller-Matero, Fatin Dubaybo, Maisa S. Ziadni, Rachel Feit, Rachel Kvamme, Anne Eshelman, William Keimig   +6 more
doaj   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Ansiedad en el paciente prequirúrgico: un problema que nos afecta a todos

Revista Colombiana de Cirugía
Introducción. La ansiedad es el estado mental que conduce al ser humano a experimentar reacciones de incomodidad, angustia, miedo, preocupación o excitación.
Andrea Quintero, Diana A. Yasnó, Olga L. Riveros, Jeisson Castillo, Bernardo A. Borráez   +4 more
doaj  

The association of sleep disordered breathing with left ventricular remodeling in CAD patients: a cross-sectional study

BMC Cardiovascular Disorders, 2017
Background There is still insufficient knowledge on the potential effect of mild to moderate sleep-disordered breathing (SDB) that is widely prevalent, often asymptomatic, and largely undiagnosed in patients with stable coronary artery disease (CAD). SDB
Audrius Alonderis, Nijole Raskauskiene, Vaidute Gelziniene, Narseta Mickuviene, Julija Brozaitiene   +4 more
doaj   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source