Results 111 to 120 of about 872,884 (298)
Molecular Oncology, EarlyView.Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang +12 more
wiley +1 more source
Comprehensive Security Framework for Global Threats Analysis [PDF]
, 2009 Cyber criminality activities are changing and becoming more and more professional. With the growth of financial flows through the Internet and the Information System (IS), new kinds of thread arise involving complex scenarios spread within multiple IS ...
Benali, Fatiha +2 more
core +3 more sources
A Stochastic Hybrid Framework for Driver Behavior Modeling Based on Hierarchical Dirichlet Process
, 2018 Scalability is one of the major issues for real-world Vehicle-to-Vehicle network realization. To tackle this challenge, a stochastic hybrid modeling framework based on a non-parametric Bayesian inference method, i.e., hierarchical Dirichlet process (HDP),
Fallah, Yaser P. +2 more
core +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
IEEE AccessIn this work, a formulation of alternating direction method of multipliers (ADMM) for addressing power amplifiers (PA) modeling and linearization problems is presented. The proposal consists on leveraging the implicit redundancy of the equations in order
Elias Marques-Valderrama +2 more
doaj +1 more source
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
IEEE AccessWith the deepening application of artificial intelligence in the field of education, teaching quality evaluation has become the key to improving educational effectiveness.
Tong Lei, Yao Yan, Baoshan Zhang
doaj +1 more source
Learning and Production of Movement Sequences: Behavioral, Neurophysiological, and Modeling Perspectives [PDF]
, 2003 A growing wave of behavioral studies, using a wide variety of paradigms that were introduced or greatly refined in recent years, has generated a new wealth of parametric observations about serial order behavior.
Averbeck, Bruno +4 more
core +1 more source
Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source