Results 121 to 130 of about 251,773 (308)

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

open access: yesMolecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova   +14 more
wiley   +1 more source

A behavioral view of Nevanlinna-Pick interpolation

open access: yes, 2005
The classical Nevanlinna-Pick (NP) interpolation problem is about finding a rational function that satisfies given interpolation conditions, along with a norm condition.
PILLAI, HARISH K   +3 more
core  

Modeling of a combustion engine with hardware description languages

open access: yes, 2022
Modeling of mechanical components in hardware description languages is the key for the verification and optimization of mechatronic systems on the basis of a circuit simulator. To illustrate this, the paper explores the model development for a combustion
Kowalewski, T.   +3 more
core  

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

open access: yesMolecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Behavioral Queueing: An Agent Based Modeling Approach

open access: yes, 2011
Queueing research has a plethora of applications and has been an area of study spanning from telecommunications to economics. Traditionally, studies on queueing has mainly concentrated on design, performance and running of the service facility with ...
Sankaranarayanan, K.   +3 more
core  

Modeling of embedded software for automotive applications

open access: yes, 2022
S.123-128The primary objective of this paper is to support the design of electronics and embedded software for automotive applications. To accomplish this, we developed a new modeling paradigm based on models of software and the extensive use of analog ...
Pelz, G., Zimmer, G., Bielefeld, J.
core  

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

open access: yesMolecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak   +10 more
wiley   +1 more source

Implementation of Alternating Direction Method of Multipliers for Solving Power Amplifier Linearization Problem: Theoretical Foundations and Proof of Concept

open access: yesIEEE Access
In this work, a formulation of alternating direction method of multipliers (ADMM) for addressing power amplifiers (PA) modeling and linearization problems is presented. The proposal consists on leveraging the implicit redundancy of the equations in order
Elias Marques-Valderrama   +2 more
doaj   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

open access: yesMolecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi   +7 more
wiley   +1 more source

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