Results 141 to 150 of about 251,773 (308)

Promiscuous stimulation of HSP70 ATPase activity by parasite‐derived J‐domains

FEBS Open Bio, EarlyView.
The malaria parasite Plasmodium falciparum exports three highly homologous yet functionally divergent J‐domain proteins into human erythrocytes. Here, we show that J‐domains isolated from all three proteins effectively stimulate the ATPase activity of both endogenous host and exported parasite HSP70 chaperones.
Julian Barth, Moritz Koch, Le‐Han Rössner, Johanna Eichhorn, Denys Pogoryelov, Matthias P. Mayer, Jude M. Przyborski   +6 more
wiley   +1 more source

Quaternary Correlation Prediction Compensation for Heading Commands in Virtual Autopilot

Aerospace
Virtual commands serve as the essential framework for establishing interaction between the virtual pilot and the MCP in autopilot scenarios. Conventional proportional-integral-derivative (PID) controllers are insufficient to ensure accurate flight ...
Yutong Zhou, Shan Fu
doaj   +1 more source

Hybrid Modeling: New Answers to Old Challenges [PDF]

After nearly two decades of debate and fundamental disagreement, topdown and bottom-up energy-economy modelers, sometimes referred to as modeling ‘tribes', began to engage in productive dialogue in the mid-1990s (IPCC 2001).
Mark Jaccard, Frédéric Ghersi, Jean Charles Hourcade, Chris Bataille   +3 more
core  

Exon 7 splicing of ERα predicts poor prognosis and increases phenotypic heterogeneity in luminal a subtype breast cancer

FEBS Open Bio, EarlyView.
ERα splice variant ERα∆7 lacks the C‐terminus, and its expression may change phenotypes of breast cancers. Our results showed that ERα∆7 is found in the luminal A subtype, and elevated ERα∆7 levels are linked to improved cell survival with lower proliferation and migration.
Long Wai Tsui, Taobo Hu, Thomson Christian Husein, Wai Hei Shek, Bingrong Chen, Depeng Wang, Shu Wang, Weichuan Yu, Xiaodan Fan, Mengping Long, Toyotaka Ishibashi   +10 more
wiley   +1 more source

A Multi-Level Modeling Framework for Detecting Hidden Risk Patterns in Complex Online Information Environments

Applied Sciences
In the context of increasingly multi-source and complex online financial information dissemination, traditional single-modality risk detection methods are insufficient for effectively identifying highly concealed and coordinated financial risk behaviors.
Rong Fu, Jiahong Pu, Jieli Chen, Wenhui Wang, Fuye Zhang, Yi Wei, Manzhou Li   +6 more
doaj   +1 more source

Function-Based Behavioral Modeling

, 2007
Behavioral models, mathematical models of a system\u27s ability to meet customer needs, are useful evaluation tools throughout the design process of systems. Currently, behavioral modeling is conducted at a component level.
Hutcheson, Ryan S., McAdams, Daniel A., Tumer, Irem Y., Stone, Robert B.   +3 more
core  

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source

GPT-4 in Forensic Role Simulations Through a Psycholinguistic Lens: Emotional Realism, Narrative Structure, and Identity Continuity

Психолінгвістика
Purpose. This study investigates how GPT-4 performs in forensic role simulations when examined through a psycholinguistic lens. The analysis focuses on whether the model can generate emotionally realistic, narratively coherent, and identity-consistent ...
Віталій Шимко, Анжела Бабаджанова, Олександр Сафін   +2 more
doaj   +1 more source

System verification of flexray communication networks through behavioral simulations

, 2010
Internal vehicle communication networks are becoming highly distributed systems. The increase of the internal vehicle electronic system complexity requires higher performance and reliability, and the necessity of ensuring enough bus signal integrity ...
Maurizio Valle, Candice Muller, VALLE, MAURIZIO, MULLER, CANDICE   +3 more
core   +1 more source

Screening and epitope characterization of Nidogen‐2‐specific nanobodies

FEBS Open Bio, EarlyView.
Camel immunization and phage display were employed to generate high‐affinity VHH nanobodies against Nidogen‐2. After library construction, biopanning, ELISA screening, sequencing, and recombinant expression, selected nanobodies were purified and characterized, leading to the preliminary exploration of a nanobody‐based sandwich ELISA for specific ...
Jianchuan Wen, Qianqian Cui, Zhongyun Lan, Yingjun Wang, Shuaiying Zhao, Wenxuan Feng, Yunfeng Liu, Qiting Huang, Dongna Zhang, Jianfeng Xu   +9 more
wiley   +1 more source