Results 1 to 10 of about 263,500 (249)
iScience, 2023 Summary: The insular cortex (insula) is known to play a modulatory role in feeding and drinking. Previous studies have revealed anterior-posterior differences of subcortical projections and roles for the insula, yet the anatomical and functional ...
Makoto Takemoto +3 more
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Dissociation of tic generation from tic expression during the sleep-wake cycle
iScience, 2021 Summary: Motor tics, the hallmark of Tourette syndrome (TS), are modulated by different behavioral and environmental factors. A major modulating factor is the sleep-wake cycle in which tics are attenuated to a large extent during sleep.
Esther Vinner Harduf +3 more
doaj +1 more source
Dopamine-mediated striatal activity and function is enhanced in GlyRα2 knockout animals
iScience, 2023 Summary: The glycine receptor alpha 2 (GlyRα2) is a ligand-gated ion channel which upon activation induces a chloride conductance. Here, we investigated the role of GlyRα2 in dopamine-stimulated striatal cell activity and behavior. We show that depletion
Jens Devoght +12 more
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Countermanding Perceptual Decision-Making
iScience, 2020 Summary: We investigated whether a task requiring concurrent perceptual decision-making and response control can be performed concurrently, whether evidence accumulation and response control are accomplished by the same neurons, and whether perceptual ...
Paul G. Middlebrooks +4 more
doaj +1 more source
iScience, 2021 Summary: The paraventricular nucleus of the thalamus (PVT) controls goal-oriented behavior through its connections to the nucleus accumbens (NAc). We previously characterized Glut2aPVT neurons that are activated by hypoglycemia, and which increase ...
Sébastien Kessler +5 more
doaj +1 more source
Comparative Perspectives that Challenge Brain Warming as the Primary Function of REM Sleep
iScience, 2020 Summary: Rapid eye movement (REM) sleep is a paradoxical state of wake-like brain activity occurring after non-REM (NREM) sleep in mammals and birds.
Gianina Ungurean +4 more
doaj +1 more source
iScience, 2022 Summary: The mechanisms underlying sleep homeostasis are poorly understood. The nematode Caenorhabditis elegans exhibits 2 types of sleep: lethargus, or developmentally timed, and stress-induced sleep.
Shinichi Miyazaki +3 more
doaj +1 more source
Neuroimmune Responses Mediate Depression-Related Behaviors following Acute Colitis
iScience, 2019 Summary: Many patients with visceral inflammation develop pain and psychiatric comorbidities such as major depressive disorder, worsening the quality of life and increasing the risk of suicide.
Vinicius M. Gadotti +10 more
doaj +1 more source
The Reconfigurable Maze Provides Flexible, Scalable, Reproducible, and Repeatable Tests
iScience, 2020 Summary: Multiple mazes are routinely used to test the performance of animals because each has disadvantages inherent to its shape. However, the maze shape cannot be flexibly and rapidly reproduced in a repeatable and scalable way in a single environment.
Satoshi Hoshino +6 more
doaj +1 more source
Emergence of rhythmic chunking in complex stepping of mice
iScience, 2023 Summary: Motor chunking is important for motor execution, allowing atomization and efficiency of movement sequences. However, it remains unclear why and how chunks contribute to motor execution.
Kojiro Hirokane +6 more
doaj +1 more source