Results 21 to 30 of about 263,500 (249)

Ablation of Ventral Midbrain/Pons GABA Neurons Induces Mania-like Behaviors with Altered Sleep Homeostasis and Dopamine D2R-mediated Sleep Reduction

iScience, 2020
Summary: Individuals with the neuropsychiatric disorder mania exhibit hyperactivity, elevated mood, and a decreased need for sleep. The brain areas and neuronal populations involved in mania-like behaviors, however, have not been elucidated.
Takato Honda, Yohko Takata, Yoan Cherasse, Seiya Mizuno, Fumihiro Sugiyama, Satoru Takahashi, Hiromasa Funato, Masashi Yanagisawa, Michael Lazarus, Yo Oishi   +9 more
doaj   +1 more source

Antidepressant Effects of (S)-Ketamine through a Reduction of Hyperpolarization-Activated Current Ih

iScience, 2020
Summary: Compelling evidence suggests that a single sub-anesthetic dose of (R,S)-ketamine exerts rapid and robust antidepressant effects. However, the cellular mechanisms underlying the antidepressant effects of (R,S)-ketamine remain unclear.
Chung Sub Kim, Daniel Johnston
doaj   +1 more source

Ingestion of probiotic (Lactobacillus helveticus and Bifidobacterium longum) alters intestinal microbial structure and behavioral expression following social defeat stress

Scientific Reports, 2021
Social stress exacerbates anxious and depressive behaviors in humans. Similarly, anxiety- and depressive-like behaviors are triggered by social stress in a variety of non-human animals.
Katherine A. Partrick, Anna M. Rosenhauer, Jérémie Auger, Amanda R. Arnold, Nicole M. Ronczkowski, Lanaya M. Jackson, Magen N. Lord, Sara M. Abdulla, Benoit Chassaing, Kim L. Huhman   +9 more
doaj   +1 more source

Acetylcholine Regulates Olfactory Perceptual Learning through Effects on Adult Neurogenesis

iScience, 2019
Summary: Learning to perceptually discriminate between chemical signals in the environment (olfactory perceptual learning [OPL]) is critical for survival.
Arielle Schilit Nitenson, Gabriela Manzano Nieves, Devon Lynn Poeta, Ryan Bahar, Carolyn Rachofsky, Nathalie Mandairon, Kevin G. Bath   +6 more
doaj   +1 more source

Numerosity perception is tuned to salient environmental features

iScience, 2022
Summary: Numerosity perception is a key ability to guide behavior. However, current models propose that number units encode an abstract representation of numerosity regardless of the non-numerical attributes of the stimuli, suggesting rather coarse ...
Paolo Antonino Grasso, Giovanni Anobile, Roberto Arrighi, David Charles Burr, Guido Marco Cicchini   +4 more
doaj   +1 more source

How and when EEG reflects changes in neuronal connectivity due to time awake

iScience, 2023
Summary: Being awake means forming new memories, primarily by strengthening neuronal synapses. The increase in synaptic strength results in increasing neuronal synchronicity, which should result in higher amplitude electroencephalography (EEG ...
Sophia Snipes, Elias Meier, Sarah Nadine Meissner, Hans-Peter Landolt, Reto Huber   +4 more
doaj   +1 more source

Attenuation processes in positive social emotion upregulation: Disentangling functional role of ventrolateral prefrontal cortex

iScience
Summary: Positive emotions determine individual well-being and sustainable social relationships. Here, we examined the neural processes mediating upregulation of positive social emotions using functional magnetic resonance imaging in healthy female ...
Dmitriy D. Bezmaternykh, Mikhail Ye. Melnikov, Evgeny D. Petrovskiy, Ksenia G. Mazhirina, Andrey A. Savelov, Mark B. Shtark, Patrik Vuilleumier, Yury Koush   +7 more
doaj   +1 more source

Event segmentation reveals working memory forgetting rate

iScience, 2022
Summary: We encounter the world as a continuous flow and effortlessly segment sequences of events into episodes. This process of event segmentation engages working memory (WM) for tracking the flow of events and impacts subsequent memory accuracy.
Anna Jafarpour, Elizabeth A. Buffalo, Robert T. Knight, Anne G.E. Collins   +3 more
doaj   +1 more source

Dissociating neural circuits of social and prosocial reward in rat helping behavior

iScience
Summary: Helping behavior in rodents provides a powerful model for studying neurobiological underpinnings of prosocial motivation. Previously, rats allowed to release a trapped conspecific demonstrated prosocial motivation selectively toward ingroup ...
Keren Ruzal, Estherina Trachtenberg, Ben Kantor, Hila Flumin, Adin Roemer, Andres Crespo, Johannes Kohl, Inbal Ben-Ami Bartal   +7 more
doaj   +1 more source

Molecular bases of circadian magnesium rhythms across eukaryotes

FEBS Letters, EarlyView.
Circadian rhythms in intracellular [Mg2+] exist across eukaryotic kingdoms. Central roles for Mg2+ in metabolism suggest that Mg2+ rhythms could regulate daily cellular energy and metabolism. In this Perspective paper, we propose that ancestral prokaryotic transport proteins could be responsible for mediating Mg2+ rhythms and posit a feedback model ...
Helen K. Feord, Gerben van Ooijen
wiley   +1 more source