Results 41 to 50 of about 1,165,410 (265)

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

DIGITAL FILTERS IN BEHAVIORAL RESEARCH [PDF]

Journal of the Experimental Analysis of Behavior, 1983
Behavioral control is almost always less than perfect. Rate of response is rarely as constant as it could be even when the greatest care is given to experimental procedures. Experimenters should always attempt to identify the causes of variation. Some fluctuations in response rate will be random, i.e., sometimes positive and sometimes negative, usually
openaire   +2 more sources

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source

Biophysical approaches for studying viral entry

FEBS Letters, EarlyView.
Viruses infect all living organisms and have been responsible for major epidemics and pandemics. Their ongoing evolutionary battle with host defenses creates a constant need for improved tools to study viral behavior. Advancing methods to probe viral attachment, fusion, and genome release deepen our understanding of how infections begin and support the
Inbar Yosibash, Raya Sorkin
wiley   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Association between RBC Indices, Anemia, and Obesity-Related Diseases Affected by Body Mass Index in Iranian Kurdish Population: Results from a Cohort Study in Western Iran

International Journal of Endocrinology, 2021
Objective. The relationship between RBC indices and metabolic diseases remains unclear. The association between anemia and obesity is also controversial.
Maryam Kohsari, Mehdi Moradinazar, Zohreh Rahimi, Farid Najafi, Yahya Pasdar, Atefeh Moradi, Ebrahim Shakiba   +6 more
doaj   +1 more source

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

FEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas, Brigitta Maruzs, Zsófia E. Kálmán, Tomas Klumpler, Gyula Batta, Bálint Péterfia, Zoltán Gáspári   +6 more
wiley   +1 more source

Impact of the COVID-19 Pandemic on the Scientific Production of Physical Education Researchers: A Five-Year Follow-Up Study

Behavioral Sciences
The COVID-19 pandemic caused significant changes in society’s dynamics, particularly affecting the landscape of education. Research in several areas may have been affected during periods of social restrictions.
Sarah Jane Lemos de Melo, Vanderlei Porto Pinto, Emerson Sebastião, Érica de Moraes Santos Corrêa, Gustavo Christofoletti   +4 more
doaj   +1 more source

The behavioral researcher and the zoological park

Applied Animal Behaviour Science, 1984
Abstract Ethologists and psychologists have traditionally taken different approaches to the study of animal behavior. Recently, there has been something of a rapprochement between these two schools of the study of behavior. The range of animals and the number of groups available in the zoo for comparison provide a wealth of topics for study by the ...
Moran, Greg, Sorensen, Linda
openaire   +4 more sources

The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome

FEBS Letters, EarlyView.
This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley   +1 more source