Results 111 to 120 of about 1,971,830 (326)

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Long-term consequences of adolescent exposure to the synthetic cannabinoid AB-FUBINACA in male and female mice

iScience
Summary: The consumption of synthetic cannabinoids during adolescence is reported to be a risk factor for the appearance of psychiatric disorders later in life.
Cristina Izquierdo-Luengo, María Ponce-Renilla, Marc Ten-Blanco, María Andrea Arnanz, Rosa María Tolón, Inmaculada Pereda-Pérez, Fernando Berrendero   +6 more
doaj   +1 more source

Behavioral science workshops

Academic Medicine, 1985
J R, Rudisill, J, Gillen, A, Allen
openaire   +3 more sources

Is there a first mover advantage in science? Pioneering behavior and scientific production in nanotechnology

, 2017
Maréva Sabatier, Barthélemy Chollet
openalex   +2 more sources

BRINGING TOGETHER VIDEO TECHNOLOGY, RESEARCH, AND PRACTICE: A REVIEW OF PRACTICAL GUIDE TO USING VIDEO IN THE BEHAVIORAL SCIENCES BY DOWRICK AND ASSOCIATES [PDF]

, 1996
Christine L. Cole
openalex   +1 more source

Cognitive bias in animal behavior science: a philosophical perspective [PDF]

, 2022
Behzad Nematipour, Marko Bračić, Ulrich Krohs   +2 more
openalex   +1 more source

Strength through diversity: how cancers thrive when clones cooperate

Molecular Oncology, EarlyView.
Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken, Maartje Witsen, Emile E. Voest, Krijn K. Dijkstra   +3 more
wiley   +1 more source

VCU Professor Researches Early Intervention Programs for Preschools, Ties to RTR Program [PDF]

, 2015
The Institute for Education Sciences, IES, a branch of the US Department of Education, awarded a grant to VCU professors Bryce McLeod, Ph.D and Kevin Sutherland, Ph.D to research behavioral problems in local preschool children.
Giles, Sterling
core   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Edible cannabinoids impact meal structure and food impulsivity in female rats

iScience
Summary: Cannabinoid receptor agonists increase eating in a dose-dependent manner. However, the behavioral mechanisms by which cannabinoids modulate food intake control aren’t clear, particularly in females.
Magen N. Lord, Mai O. Spaulding, Jessica R. Hoffman, Rawad K. Basma, Emily E. Noble   +4 more
doaj   +1 more source