Results 131 to 140 of about 2,330,498 (293)
, 2022 Antecedentes: A doença de Coronavirus 2019 (COVID-19) é uma infecção pandémica com risco substancial de morte, deixando a população idosa na Europa numa situação bastante terrível, especialmente nos idosos. Métodos: Foram recolhidos dados demográficos por país sobre os idosos na Europa com mais de 50 anos de idade.
openaire +1 more source
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Adolescent sexuality—changing needs and values [PDF]
, 2017 Concern about the health of adolescents, their patterns of social and sexual interaction as well as the ways in which they ultimately are able to adapt to the outcomes of their interaction is a relatively recent development (Carballo & Engstrom, 1975 ...
Carballo, Manuel
core
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
BMJ OpenIntroduction The prevalence of multiple long-term conditions (M-LTCs) increases as adults age and impacts quality of life and health outcomes. To help people manage these conditions, complex behaviour change interventions are used, often based on ...
Stephanie Taylor +9 more
doaj +1 more source
Accidental injury, risk-taking behaviour and the social circumstances in which young people (aged 12-24) live: a systematic review [PDF]
, 2007 In industrialised countries such as England and Wales, unintended injury (which ranges from sprains in sport to hospitalisation and death due to drugs or transport crashes) is the leading cause of death in children aged 0 to 14 years, and a major cause ...
Burchett, Helen +5 more
core +2 more sources
FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source
Teaching pro-environmental rules: Implications for environmental education and climate change
Revista Española de PedagogíaThe concern regarding the gap between words and actions has spread through different contexts, in particular those relating to environmental education.
Leidy-Vanessa Díaz-Beltrán +1 more
doaj +1 more source