Results 111 to 120 of about 2,330,498 (293)

Being and Becoming: The Heart of Teacher Education

, 2007
Teacher education is of critical concern to a nation’s well-being. Scripture clearly identifies that the predominant narratives in a nation’s education are directly linked to its citizen’s behaviour (e.g., see Psalm 78, Judges 2). Literature which claims
Norsworthy, Bev
core  

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

What are the exercise barriers, facilitators and preferences of community-dwelling older adults with heart failure with preserved ejection fraction? A qualitative best fit framework analysis

BMJ Open
Objectives To establish, through patient and public involvement (PPI) events, the exercise barriers, facilitators and preferences of people with heart failure with preserved ejection fraction (HFpEF).Design Qualitative ‘best fit’ framework analysis was ...
Christi Deaton, Jonathan Mant, ALISON WOOD, Faye Forsyth, John Sharpley, Peter Hartley, Scott Rowbotham   +6 more
doaj   +1 more source

Clinical evaluation of education relating to nutrition and skeletal loading in competitive male road cyclists at risk of relative energy deficiency in sports (RED-S): 6-month randomised controlled trial

BMJ Open Sport & Exercise Medicine, 2019
Objective To clinically evaluate education to improve eating behaviour and skeletal loading exercise in male cyclists at risk of poor bone health and impaired performance due to relative energy deficiency in sports.Methods Early race season, 50 ...
Nicola Keay, Gavin Francis, Karen Hind, Ian Entwistle   +3 more
doaj   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

The 'Walking for Wellbeing in the West' randomised controlled trial of a pedometer-based walking programme in combination with physical activity consultation with 12 month follow-up: rationale and study design

BMC Public Health, 2008
Background Scotland has a policy aimed at increasing physical activity levels in the population, but evidence on how to achieve this is still developing.
Ogilvie David, Fenwick Elisabeth, Shaw Rebecca, Millington Catherine, Lowry Ruth, Ward Thompson Catharine, Nimmo Myra A, Wright Annemarie, Baker Graham, Fitzsimons Claire F, Inchley Joanna, Foster Charlie E, Mutrie Nanette   +12 more
doaj   +1 more source

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

FEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva, Puspa Kunwar, Md Ibnul Rifat Rahman, Joanna Koryo Kwao, Nathan Lehman, Zihan Zhang, Trenton Paul, Claire Cheng, Nicholas Truex, Hui‐Ting Lee, Jun Zhang   +10 more
wiley   +1 more source

Effectiveness and feasibility of a theory-informed intervention to improve Mediterranean diet adherence, physical activity and cognition in older adults at risk of dementia: the MedEx-UK randomised controlled trial

BMC Medicine
Background Despite an urgent need for multi-domain lifestyle interventions to reduce dementia risk, there is a lack of interventions which are informed by theory- and evidence-based behaviour change strategies, and no interventions in this domain have ...
A. Jennings, O. M. Shannon, R. Gillings, V. Lee, R. Elsworthy, R. Bundy, G. Rao, S. Hanson, W. Hardeman, S-M. Paddick, M. Siervo, S. Aldred, J. C. Mathers, M. Hornberger, A. M. Minihane   +14 more
doaj   +1 more source

Influencing recidivist drink drivers' entrenched behaviours : the self-reported outcomes of three countermeasures [PDF]

, 2004
Concern remains regarding the efficacy of drink driving countermeasures to produce lasting change for repeat offenders, as a wide array of countermeasures have been developed that demonstrate varying levels of success in reducing re-offence rates.
Freeman, James Edwin
core   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source