Results 121 to 130 of about 152,618 (296)

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Survival of the Fittest: Evidence-based Interventions for Physical Inactivity Amongst Student Populations

JANZSSA, 2017
Lack of physical activity is a problem amongst student populations given their large proportion of desk-bound activity. Attrition from physical activity programs is widespread.
Stephanie C. Black
doaj   +1 more source

Techniques, tactics and strategies for conceptual change in school science [PDF]

, 2014
This study explores how experienced science teachers promote conceptual change. It examines how instructional strategies, learning methods (Darden, 1991) and conceptual change interrelate.
Riordan, J.
core  

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Development of a behaviour change intervention to increase care home staff influenza vaccination uptake

International Journal of Nursing Studies Advances
Background: To protect care home residents the World Health Organisation recommends that 75 % of care home staff are vaccinated for influenza. In the UK this value is less than 30 %.
Amrish Patel, Sion Scott, Alys Wyn Griffiths, David Wright   +3 more
doaj   +1 more source

Identification of behaviour change techniques and engagement strategies to design a smartphone app to reduce alcohol consumption using a formal consensus method

, 2015
Background: Digital interventions to reduce excessive alcohol consumption have the potential to have a broader reach and be more cost-effective than traditional brief interventions.
Crane, D, Michie, S, Garnett, CV, Brown, J, West, R   +4 more
core  

Dataset for meta-analysis of techniques to promote motivation for health behaviour change

, 2018
This dataset was created following data extraction of a systematic review of intervention studies reported within published articles and dissertations conducted through methods described in the paper "A meta-analysis of techniques to promote motivation ...
Centre for Motivation and Behaviour Change (CMBC), EPSRC Centre for Doctoral Training in Statistical Applied Mathematics (SAMBa), Institute for Policy Research (IPR), Faculty of Humanities and Social Sciences, Centre for Qualitative Research (CQR), Gillison, Fiona, Centre for 21st Century Public Health, Department for Health   +7 more
core   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

The Behaviour Change Technique Ontology: Transforming the Behaviour Change Technique Taxonomy v1 [version 1; peer review: 3 approved]

Wellcome Open Research, 2023
Background: The Behaviour Change Technique Taxonomy v1 (BCTTv1) specifies the potentially active content of behaviour change interventions. Evaluation of BCTTv1 showed the need to extend it into a formal ontology, improve its labels and definitions, add BCTs and subdivide existing BCTs.
Robert West, Janna Hastings, Alison J. Wright, Marta M. Marques, Elizabeth Corker, Lisa Zhang, Susan Michie, Marie Johnston   +7 more
openaire   +1 more source