Results 81 to 90 of about 152,618 (296)

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Determinants of usefulness in professional behaviour change interventions: observational study of a 15-year national program

BMJ Open, 2020
Objective Educational, and audit and feedback interventions are effective in promoting health professional behaviour change and evidence adoption. However, we lack evidence to pinpoint which particular features make them most effective.
Nicole L Pratt, Andre Q Andrade, Vanessa T LeBlanc, Lisa M Kalisch-Ellett, Anna Moffat, Natalie Blacker, Kerrie Westaway, John D Barratt, Elizabeth E Roughead   +8 more
doaj   +1 more source

The development of intervention e-learning materials and implementation techniques for cyber-security behaviour change

, 2018
Many organisations show compliance in running security awareness programmes, but this does not necessarily mean end users will change their behavior. is highlights one of the main challenges in cyber security.
Skinner, Tiffany, Taylor-Jackson, Jacqui (R19920), McAlaney, John, Dale, John   +3 more
core  

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

The use of the behaviour change wheel in the development of ParticipACTION’s physical activity app

Preventive Medicine Reports, 2020
The purpose of this study was to provide a detailed and systematic outline of how a theoretical behaviour change framework was applied in the development of ParticipACTION’s app to support a more active Canada.
Stephanie Truelove, Leigh M. Vanderloo, Patricia Tucker, Katie M. Di Sebastiano, Guy Faulkner   +4 more
doaj   +1 more source

Investigating Which Behaviour Change Techniques Work for Whom in Which Contexts Delivered by What Means:Proposal for an International Collaboratory of Centres for Understanding Behaviour Change (CUBiC) [PDF]

, 2020
Purpose. Behaviour change techniques are fundamental to the development of any behaviour change intervention, but surprisingly little is known about their properties.
Marie Johnston, Prestwich, Andrew, Epton, Tracy; id_orcid, Christopher J. Armitage, de Bruin, Marijn, Armitage, Christopher J, Epton, T, Marijn de Bruin, Armitage, C J; id_orcid, Sniehotta, Falko F., Johnston, M, Prestwich, A, Epton, T., Sniehotta, F, Bruin, M. de, Armitage, CJ, Johnston, M., Sniehotta, F., Conner, M., Mark Conner, Conner, Mark, Tracy Epton, Armitage, C.J., Conner, M, Johnston, Marie, Falko Sniehotta, Sniehotta, Falko F, Epton, Tracy, de Bruin, M, Prestwich, A., Andrew Prestwich   +30 more
core   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Frequency of inclusion of behaviour change techniques.

, 2016
Frequency of inclusion of behaviour change techniques.
Laura Goodwin (479736), Giovanni Ostuzzi (2163973), Nadia Khan (2622778), Matthew H. Hotopf (2622775), Rona Moss-Morris (338974)   +4 more
core   +1 more source