Engineering Human Beige Adipose Tissue [PDF]
Frontiers in Bioengineering and Biotechnology, 2022 In this study, we described a method for generating functional, beige (thermogenic) adipose microtissues from human microvascular fragments (MVFs). The MVFs were isolated from adipose tissue acquired from adults over 50 years of age.
Maria A. Gonzalez Porras +7 more
doaj +5 more sources
Engineering Functional Vascularized Beige Adipose Tissue from Microvascular Fragments of Models of Healthy and Type II Diabetes Conditions [PDF]
Journal of Tissue Engineering, 2022 Engineered beige adipose tissues could be used for screening therapeutic strategies or as a direct treatment for obesity and metabolic disease. Microvascular fragments are vessel structures that can be directly isolated from adipose tissue and may ...
Francisca M. Acosta +6 more
doaj +5 more sources
Brown and beige adipose tissue regulate systemic metabolism through a metabolite interorgan signaling axis [PDF]
Nature Communications, 2021 Brown and beige adipose tissue are emerging as distinct endocrine organs. These tissues are functionally associated with skeletal muscle, adipose tissue metabolism and systemic energy expenditure, suggesting an interorgan signaling network.
Anna Whitehead +2 more
exaly +5 more sources
Brown and Beige Adipose Tissue and Aging [PDF]
Frontiers in Endocrinology, 2019 Across aging, adipose tissue (AT) changes its quantity and distribution: AT becomes dysfunctional with an increase in production of inflammatory peptides, a decline of those with anti-inflammatory activity and infiltration of macrophages.
Elena Zoico +7 more
doaj +7 more sources
Bioengineering beige adipose tissue therapeutics [PDF]
Frontiers in Endocrinology, 2015 Unlocking the therapeutic potential of brown/beige adipose tissue requires technological advancements that enable the controlled expansion of this uniquely thermogenic tissue.
Kevin eTharp, Andreas eStahl
doaj +6 more sources
An insight into brown/beige adipose tissue whitening, a metabolic complication of obesity with the multifactorial origin [PDF]
Frontiers in Endocrinology, 2023 Brown adipose tissue (BAT), a thermoregulatory organ known to promote energy expenditure, has been extensively studied as a potential avenue to combat obesity.
Khanyisani Ziqubu +9 more
doaj +3 more sources
<i>Ckmt1</i> is Dispensable for Mitochondrial Bioenergetics Within White/Beige Adipose Tissue. [PDF]
Function (Oxf), 2022 Within brown adipose tissue (BAT), the brain isoform of creatine kinase (CKB) has been proposed to regulate the regeneration of ADP and phosphocreatine in a futile creatine cycle (FCC) that stimulates energy expenditure. However, the presence of FCC, and
Politis-Barber V +9 more
europepmc +4 more sources
Brown and beige adipose tissue‐derived metabokine and lipokine inter‐organ signalling in health and disease [PDF]
Experimental PhysiologyAdipose tissue has an established endocrine function through the secretion of adipokines. However, a role for bioactive metabolites and lipids, termed metabokines and lipokines, is emerging in adipose tissue‐mediated autocrine, paracrine and endocrine ...
Anna Malicka +3 more
doaj +3 more sources
Brown and Beige Adipose Tissue: One or Different Targets for Treatment of Obesity and Obesity-Related Metabolic Disorders? [PDF]
Int J Mol SciThe failure of the fight against obesity makes us turn to new goals in its treatment. Now, brown adipose tissue has attracted attention as a promising target for the treatment of obesity and associated metabolic disorders such as insulin resistance ...
Kononova YA, Tuchina TP, Babenko AY.
europepmc +4 more sources
Protein Kinase SGK2 Is Induced by the β3 Adrenergic Receptor-cAMP-PKA-PGC-1α/NT-PGC-1α Axis but Dispensable for Brown/Beige Adipose Tissue Thermogenesis [PDF]
Frontiers in Physiology, 2021 Brown and beige adipocytes are specialized to dissipate energy as heat. Sgk2, encoding a serine/threonine kinase, has been identified as a brown and beige adipocyte-specific gene in rodents and humans; however, its function in brown/beige adipocytes ...
Chul-Hong Park +5 more
doaj +4 more sources