Results 71 to 80 of about 1,631,664 (286)

ALDOA Promotes Glycolysis and NLRP3/GSDMD Pyroptosis to Accelerate ALS Progression

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Amyotrophic lateral sclerosis (ALS) is characterized by progressive motor neuron degeneration. Glycolytic dysregulation is implicated in disease progression, yet the underlying mechanisms remain unclear. This study investigates how Aldolase A (ALDOA) drives ALS progression through glycolysis‐mediated motor neuron pyroptosis.
Kaixin Yan, Yan Jiang, Yuxuan Yong, Tianshuo Zhang, Niannian Zhang, Qianqian Zeng, Xue Gong, Li Meng, Fangfang Bi, Yongmin Liu   +9 more
wiley   +1 more source

Cost-utility analysis of newborn hepatitis B immunization in Beijing

Human Vaccines & Immunotherapeutics, 2021
Objectives To evaluate cost-utility of universal Hepatitis B vaccination program in the Beijing city (Beijing). Methods A decision-Markov model was constructed to determine the cost-utility of the universal immunization program for infants (universal ...
Yiwei Guo, Yong Yang, Qian Bai, Zhengwei Huang, Zongwu Wang, Dongxia Cai, Shuo Li, Xiaowei Man, Xuefeng Shi   +8 more
doaj   +1 more source

Clinical Outcomes of SEEG‐Guided Radiofrequency Thermocoagulation in Children With Focal Drug‐Resistant Epilepsy: A Multicenter Real‐World Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Stereoelectroencephalography‐guided radiofrequency thermocoagulation (SEEG‐RFTC) has emerged as a safe and effective minimally invasive treatment for children with drug‐resistant focal epilepsy. Although evidence from real‐world studies remains limited, numerous pediatric cases have demonstrated promising outcomes. This retrospective
Weitao Chen, Stéphane Jean, Weihong Liu, Yihai Dai, Xinrong Fang, Xiaoqiang Wei, Shan Chen, Shiwei Song   +7 more
wiley   +1 more source

RNA Sequencing Resolves Cryptic Pathogenic Variants in Mitochondrial Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Mitochondrial diseases are the most common inherited metabolic disorders, characterized by pronounced clinical and genetic heterogeneity that complicates molecular diagnosis. Although DNA‐based sequencing approaches have become standard in genetic testing, up to half of patients remain without a definitive diagnosis.
Zhimei Liu, Xin Duan, Fatemeh Peymani, Jia Wang, Chengjia Bao, Chaolong Xu, Ying Zou, Zixuan Zhang, Yunxi Zhang, Tongyue Li, Martin Pavlov, Junling Wang, Minhan Song, Tianyu Song, Xiaodi Han, Mingxi Sun, Danmin Shen, Ruoyu Duan, Huafang Jiang, Manting Xu, Holger Prokisch, Fang Fang   +21 more
wiley   +1 more source

Emergency shelters location-allocation problem concerning uncertainty and limited resources: a multi-objective optimization with a case study in the Central area of Beijing, China

Geomatics, Natural Hazards & Risk, 2019
The special planning for shelters is an integral part of overall city planning and is a key issue in solving the urban security problem. During the planning of earthquake emergency shelters, it is usually necessary to prioritize the designated shelters ...
Yunjia Ma, Wei Xu, Lianjie Qin, Xiujuan Zhao, Juan Du   +4 more
doaj   +1 more source

Security in Beijing 2008 and Beyond [PDF]

, 2008
In the lead-up to the 2008 Olympics, HRIC has been monitoring key aspects of preparationsfor the Beijing Games, including sponsorships, venue construction and the Chinese government's commitments as host of the Games.

core  

Charmonia from Lattice QCD [PDF]

, 2006
Recent lattice QCD results on charmonium properties are reviewed. I comment on molecules and hybrid states as well as on future studies of states near strong decay thresholds.Comment: 8 pages, 5 figures, Invited talk presented at ``Charm 2006 ...
Choe S., de Forcrand P., Gottlieb S., GUNNAR S. BALI, Zee A.   +4 more
core   +3 more sources

High‐Resolution MRI Revealed Different Etiology‐Specific Associations With Cerebral Infarction in Adult Moyamoya Vasculopathy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective High‐resolution MRI enables detailed assessment of intracranial vessel wall pathology in moyamoya vasculopathy. We aimed to classify adult moyamoya vasculopathy etiologies using high‐resolution MRI and to examine subtype‐specific associations between high‐resolution MRI features and ischemic infarction.
Guangsong Han, Jiachun Pan, Yuehui Hong, Xiaoyuan Fan, Ming Yao, Lixin Zhou, Yicheng Zhu, Feng Feng, Jun Ni   +8 more
wiley   +1 more source

Choroid Plexus Enlargement and USPIO‐Based Inflammatory Feature in Cerebral Small Vessel Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective The choroid plexus (CP) is a key component of the blood–cerebrospinal fluid barrier (BCSFB), but its mechanism of action in cerebral small vessel disease (CSVD) remains unclear. This study investigated CP volume (CPV) alterations and their association with conventional imaging markers in CSVD and explored the underlying role of ...
Yongqiang Qu, Xiaoning Ren, Cuihua Fan, Chun Li, Lijie Zhang, Zaiqiang Zhang, Shaowu Li, Zhongmeng Lai, Bin Cai, Ying Fu, Yi Lin, Zhibao Zhu   +11 more
wiley   +1 more source

SPECIFIC GENETIC FEATURES OF TUBERCULOUS MYCOBACTERIA IN URAL FEDERAL DISTRICT OF RUSSIA

Туберкулез и болезни лёгких, 2016
The article presents molecular genetic description of isolates of Mycobacterium tuberculosis of 178 new patients and 78 patients who had been previously treated obtained in 2009-2011 on the territory of Urals.
T. V. Umpeleva, A. A. Vyazovaya, N. I. Eremeeva, M. A. Kravchenko, O. V. Narvskaya, S. N. Skornyakov   +5 more
doaj   +1 more source