Results 41 to 50 of about 447,766 (259)

"LETTER TO THE KING" BY JULES DESTRY: FROM SEPARATISM TO UNITARISM IN BELGIUM

Vestnik MGIMO-Universiteta, 2016
Contradictions between the regions of Belgium - Wallonia and Flanders - have a long history associated with uneven political, economic and cultural development of the territories, which in 1830 became parts of an independent state, the Kingdom of Belgium.
E. V. Ermakova
doaj   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Who is Responsible for Instability in the Democratic Republic of Congo?

Vestnik MGIMO-Universiteta, 2014
The research focuses on the problem of military-political instability in the Democratic Republic of the Congo experiencing continued armed conflict for a long time.
G. M. Sidorova
doaj   +1 more source

Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis

Molecular Oncology, EarlyView.
This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht, Sameer Gupta, Amrita Chaurasia, Manisha Sachan   +3 more
wiley   +1 more source

Is Protest Only Negative? Examining the Effect of Emotions and Affective Polarization on Protest Behaviour

Politics and Governance, 2022
This contribution sheds light on the link between affect and protest behaviors. Using data from a voter survey conducted around the 2019 elections in Belgium, we examine two dimensions of affect: a vertical one, i.e., negative and positive emotions ...
Luca Bettarelli, Caroline Close, Emilie van Haute   +2 more
doaj   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Is academic freedom in Belgium and the Netherlands under duress? [PDF]

Pravni Zapisi
Academic freedom is considered a cornerstone of democratic higher education, yet its institutional foundations are becoming increasingly fragile. This article examines how financial austerity and ideological contestation interact to reshape academic ...
Geuens Maaike
doaj   +1 more source

Trends in Living Arrangements for Older Persons in Estonia Compared to Belgium

Studies of Transition States and Societies, 2022
The proportion of older people is increasing. During the years lived with disease and functional mobility loss, ensuring their well-being becomes a challenge for society. In addition to health, well-being in old age depends on various circumstances of an
Anne Herm, Michel Poulain
doaj   +1 more source

Effects of IGFBP4 deficiency on human preadipocyte proliferation and differentiation through the IGF1R/AKT pathway

FEBS Open Bio, EarlyView.
IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo, Sandy Richter, Christoph Bach, Wieland Kiess, Anna Kirstein, Diana Le Duc, Antje Garten   +6 more
wiley   +1 more source

Mass immigrations in the 21st century. Case of Belgium and the Netherlands

European Spatial Research and Policy, 2019
The uncontrolled wave of immigrants to the European Union countries, which reached its peak in 2015, challenged not only the well-established system of asylum policies in the Member States but also revealed the fundamental differences among them ...
Ryszard Żelichowski
doaj   +1 more source