Results 51 to 60 of about 760,634 (252)

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

Erlotinib and bevacizumab in patients with advanced non-small-cell lung cancer and activating EGFR mutations (BELIEF): an international, multicentre, single-arm, phase 2 trial. [PDF]

, 2017
BACKGROUND The tyrosine kinase inhibitor erlotinib improves the outcomes of patients with advanced non-small-cell lung carcinoma (NSCLC) harbouring epidermal growth factor receptor (EGFR) mutations.
Coate, L., Reguart, N, Froesch, P., Pless, M., Puente, J., Kotsakis, A., Ruepp, B., Karachaliou, N., Hanrahan, E., Curioni-Fontecedro, A, Früh, M, Rauch, Daniel, Puente, J, Favaretto, A, Hanrahan, E, Camps, C, Peters, S, Porta, R., Shames, D.S., Dafni, U., Gautschi, O., Majem, M, Shah, R, Früh, M., Karachaliou, N, Massuti, B, Rabaglio, Manuela, Cuffe, S, Barlesi, F., Carcereny, E, Pless, M, Shah, R., Barlesi, F, Gomez-Codina, J, Palmero, R, Bidoli, P, Tam, R., Porta, R, Carcereny, E., Rosell, Rafael, Kassapian, M, Stahel, RA, Ruepp, B, Stahel, R.A., Tam, R, Rosell, R., Reguart, N., Rabaglio, M., Dafni, Urania, Cuffe, S., Kotsakis, A, Felip, E., Coate, L, Aix, SP, Felip, E, Kammler, R, Gómez-Codina, J., Kassapian, M., Aix, S.P., Froesch, P, Molina-Vila, M.A., Thomas, M., Gautschi, O, Popat, S, Shames, DS, Curioni-Fontecedro, A., Popat, S., Bidoli, P., Favaretto, A., Peters, S., Massutí, B., Palmero, R., Majem, M., Thomas, M, Camps, C., Molina-Vila, MA, Rauch, D., Kammler, R.   +77 more
core   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Personality and paranormal belief: a study among adolescents [PDF]

, 2007
A sample of 279 13- to 16-year-old adolescents completed the Short-form Revised Junior Eysenck Personality Questionnaire (JEPQR-S) and a six-item Index of Paranormal Belief.
Robbins, Mandy, Williams, Emyr, Francis, Leslie J.   +2 more
core   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Evolving belief and being human: The emergence of religion in science and theology

Verbum et Ecclesia
Every human society as well as almost all human life is infused with ethics. There is common acknowledgement that morality and ethics are indispensable in addressing the serious global challenges humanity is faced with today.
Bernice Serfontein
doaj   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source