Results 91 to 100 of about 141,623 (240)

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

open access: yesFEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil   +4 more
wiley   +1 more source

Probabilistic Transformations of Belief Functions [PDF]

open access: yes, 2005
Alternative approaches to the widely known pignistic transformation of belief functions are presented and analyzed. A series of various probabilistic transformations is examined namely from the point of view of their consistency with rules for belief function combination and their consistency with probabilistic upper and lower bounds.A new definition ...
openaire   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

open access: yesFEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Fuzzy logic based on Belief and Disbelief membership functions

open access: yesFuzzy Information and Engineering, 2017
Many theories are developed based on probability to deal with incomplete information. The fuzzy logic deals with belief rather than likelihood (probability). Zadeh first defined fuzzy set as a single membership function.
Poli Venkata Subba Reddy
doaj   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

open access: yesFEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa   +2 more
wiley   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

open access: yesFEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar   +4 more
wiley   +1 more source

Divergence Measure of Belief Function and Its Application in Data Fusion

open access: yesIEEE Access, 2019
Divergence measure is widely used in many applications. To efficiently deal with uncertainty in real applications, basic probability assignment (BPA) in Dempster-Shafer evidence theory, instead of probability distribution, is adopted.
Yutong Song, Yong Deng
doaj   +1 more source

Belief functions on real numbers

open access: yesInternational Journal of Approximate Reasoning, 2005
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
openaire   +3 more sources

Reconstructing enzyme evolution by protein engineering

open access: yesFEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler   +2 more
wiley   +1 more source

Consistent transformations of belief functions

open access: yesCoRR, 2014
Consistent belief functions represent collections of coherent or non-contradictory pieces of evidence, but most of all they are the counterparts of consistent knowledge bases in belief calculus. The use of consistent transformations cs[.] in a reasoning process to guarantee coherence can therefore be desirable, and generalizes similar techniques in ...
openaire   +2 more sources

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