Results 111 to 120 of about 24,006 (215)

The dysconnection hypothesis of schizophrenia: a 30-year update. [PDF]

World Psychiatry
Friston K.
europepmc   +1 more source

A Second Pathogenic Protein, PolyGN2C‐iso2, Reveals a Dual‐Protein Pathology in Neuronal Intranuclear Inclusion Disease

Advanced Science, EarlyView.
This study reveals that NOTCH2NLC transcript variant 2 generates PolyGN2C‐iso2, an aggregating protein present within intranuclear inclusions of NIID patient tissues. A novel mouse model expressing PolyGN2C‐iso2 recapitulates white matter abnormalities and cognitive deficits, mechanistically linked to mitochondrial dysfunction. These findings support a
Kang Zhang, Wenhao Ma, Yi Zhou, Zhijie Wu, Pan Gao, Hongze Niu, Hongfei Tai, Tianyi Zhao, Zheyue Dong, Li Li, Yan Zhang, An Wang, Si Shen, Yueyang Li, Sifei Yu, Yan Peng, Wang Sheng, Xiaoyan Dong, Hua Pan, Kaibin Shi, Magdalena J. Koziol, Xiaobing Wu, Zaiqiang Zhang   +22 more
wiley   +1 more source

Intermittent Active Inference. [PDF]

Entropy (Basel)
Klar M, Stein S, Paterson F, Williamson JH, Gollee H, Murray-Smith R.   +5 more
europepmc   +1 more source

Pyrazole‐Derived Antibacterial Compounds Effectively Treat Methicillin‐Resistant Staphylococcus Aureus Infections by Inhibiting Aspartate Transcarbamoylase

Advanced Science, EarlyView.
This study unveils a novel antibacterial mechanism against MRSA, in which the compound Py‐27 selectively targets and inhibits aspartate transcarbamoylase (ATCase), a key enzyme in pyrimidine synthesis. This inhibition disrupts DNA replication, induces oxidative damage, leading to potent bactericidal activity.
Xiaorong Yang, Xinyuan Cao, Lixia Dai, Feng Yang, Jing Wang, Yudong Ma, Tong Bu, Zile Gong, Xueyan Liu, Changcai Bai, Xiaolou Miao, Xiaofei Shang   +11 more
wiley   +1 more source

Non-specific increase in alpha power during a neurofeedback session targeting its downregulation. [PDF]

Imaging Neurosci (Camb)
Maaz J, Dia A, Waroquier L, Paban V, Rey A.   +4 more
europepmc   +1 more source

Fundamental Challenges, Physical Implementations, and Integration Strategies for Ising Machines in Large‐Scale Optimization Tasks

Advanced Electronic Materials, EarlyView.
Ising machines are emerging as specialized hardware solvers for computationally hard optimization problems. This review examines five major platforms—digital CMOS, analog CMOS, emerging devices, coherent optics, and quantum systems—highlighting physics‐rooted advantages and shared bottlenecks in scalability and connectivity.
Hyunjun Lee, Joon Pyo Kim, Sanghyeon Kim
wiley   +1 more source

Chaotic Itinerancy in Collective Behaviour Emerging from Active Inference: A Multi-Agent Model of Trust and Empowerment Dynamics in Theatre Workshops. [PDF]

Entropy (Basel)
Miyano S, Shiono T.
europepmc   +1 more source

Ion‐Gating Reservoir Computing for Preprocessing‐Free Speech Recognition from Throat Vibrations

Advanced Electronic Materials, EarlyView.
This work presents a throat‐mounted mechanoelectric sensor integrated with an ion‐gel/graphene reservoir device for on‐device speech recognition. The system converts raw biomechanical vibrations into rich nonlinear current dynamics, enabling efficient classification through a simple linear readout. The approach highlights a compact and tunable physical‐
Daiki Nishioka, Akito Tateyama, Hina Kitano, Takashi Nakanishi, Kazuya Terabe, Takashi Tsuchiya   +5 more
wiley   +1 more source

Bridging Expectation Signals

Proceedings of the International Florida Artificial Intelligence Research Society Conference
As LLMs increasingly function as economic agents, the specific mechanisms LLMs use to update their belief with heterogeneous signals remain opaque. We design experiments and develop a Behavioral Kalman Filter framework to quantify how LLM-based agents ...
Yu Wang, Xiangchen Liu
doaj  

A New Interval Belief Rule Base Model Based on Hybrid Optimization and Adaptive Reference Intervals for Diesel Engine Health State Assessment. [PDF]

Sensors (Basel)
Zheng H, Xu B, Zhao M, Du H, He W.
europepmc   +1 more source