Results 81 to 90 of about 962,140 (259)
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Stated versus inferred beliefs: A methodological inquiry and experimental test [PDF]
If asking subjects their beliefs during repeated game play changes the way those subjects play, using those stated beliefs to evaluate and compare theories of strategic behavior is problematic.
Wilcox, Nathaniel, Rutstrom, E. Elizabet
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Ontological beliefs and their impact on teaching elementary geometry [PDF]
, 2011 This paper proposes a conceptual framework to classify ontological beliefs on elementary geometry. As a first application, this framework is used to interpret nine interviews taken from secondary school teachers. The interpretation leads to the following
Girnat, Boris
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Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
FEBS Letters, EarlyView.This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
wiley +1 more source
FEBS Letters, EarlyView.How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley +1 more source
Current state of research on mathematical beliefs 6 Proceedings
, 1998 The papers in this volume - which was prepared by the Finnish-German research group MAVI (MAthematical VIews on Beliefs and Mathematical Education) -contain the abstracts of talks given at the sixth workshop on ''Current State of Research on Mathematical
Duisburg Univ. (Gesamthochschule) (Germany). Fachbereich 11 - Mathematik +1 more
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Adolescents, beliefs and help-seeking [PDF]
, 2019 Background. Mental health services remains the least preferred choice for help-seeking in adolescents. To date, there is scarce literature regarding adolescents’ beliefs about mental health services and how their beliefs have impacted on the decision to ...
Pascua-Leones, K.
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Beliefs around luck : confirming the empirical conceptualization of beliefs around luck and the development of the Darke and Freedman beliefs around luck scale [PDF]
, 2008 The current study developed a multi-dimensional measure of beliefs around luck. Two studies introduced the Darke and Freedman beliefs around luck scale where the scale showed a consistent 4 component model (beliefs in luck, rejection of luck, being lucky,
Wood, Alex M. +6 more
core +1 more source
Chiral separation of chloroalkanes with the chromatographic column onboard Martian rovers
FEBS Letters, EarlyView.Computer image of the Rosalind Franklin Rover of ESA's ExoMars mission. ExoMars is scheduled to land on planet Mars in Oxia Planum in 2029. This area represents an interesting spot to look for biosignatures. Investigations of ExoMars include measurement on molecular chirality. We show that chiral chloroalkanes, that have been identified on Mars, can be
Asma Merzougui +4 more
wiley +1 more source