Results 61 to 70 of about 125 (122)
Acta Paediatrica, EarlyView.ABSTRACT Aims To investigate the association between serum ALP levels and the development of AKI in paediatric patients with sepsis. Methods Retrospective screening of a computerized database of 4 Israeli regional hospitals for children (0–18 years) hospitalized between 1.01.2000–1.06.2024 with ICD‐9 sepsis‐related diagnoses (study group) and age‐ and ...
Evgenia Gurevich +5 more
wiley +1 more source
Covalent drug discovery: Progress against key targets, emerging strategies and lessons learnt
British Journal of Pharmacology, EarlyView.Abstract Covalent drug discovery is currently experiencing a boom in industrial and academic interest. To date, at least 75 covalent drugs have received regulatory approval, targeting both traditional target classes and more challenging proteins for which other approaches failed. In many cases, unique aspects of covalent targeting are essential for the
Charles P. Brown +2 more
wiley +1 more source
Cancer Science, EarlyView.Mice expressing only mutant PTEN Y138L, a protein which shows normal suppression of cellular AKT yet lacks protein phosphatase activity, die in utero, and heterozygous mice display a range of tumors. This indicates both the lipid and protein phosphatase activities of PTEN work together for normal tumor suppression and embryonic development.
Priyanka Tibarewal +16 more
wiley +1 more source
The FEBS Journal, EarlyView.Blocking protein quality control degradation by deleting the E3 ligases Ubr1 or San1 stabilizes many DHFR insertion and deletion variants that are otherwise partially unfolded. These hypomorphic variants regain folding at lower temperatures or upon methotrexate binding, revealing that PQC degradation can remove proteins that are still functionally ...
Sven Larsen‐Ledet +6 more
wiley +1 more source
TOP1MT rs2293925 is an enhancer‐active regulatory SNP that shapes mitochondrial R‐loop dynamics
The FEBS Journal, EarlyView.This study shows how a common genetic variant of mitochondrial topoisomerase 1 (TOP1MT rs2293925) can influence mitochondrial gene regulation, DNA topology, and formation of noncanonical nucleic acid structures such as R‐loops. By linking this enhancer‐active variant to mitochondrial nucleic acid stress in cellular contexts relevant to amyotrophic ...
Dóra Varga +15 more
wiley +1 more source
History and Theory, EarlyView.ABSTRACT As a periodization that is generally understood to refer to an era of Terrestrial relationships that developed with modernization and nuclearization, the Anthropocene cannot be applied simply to premodern histories and texts. However, it has introduced historians to geological periodization as a mode of describing periods of changed ...
Gwenffrewi J. Morgan
wiley +1 more source
A review of skin microbiome and new challenges to cosmetic microbiome‐friendly formulations
International Journal of Cosmetic Science, EarlyView.Microbiome‐friendly concepts offer new perspectives for a healthy relationship between cosmetic use and the skin microbiome, especially the interaction of non‐biotic cosmetic ingredients with the skin, requiring further studies to clarify the dynamics between the skin microbiome and different classes of cosmetic ingredients.
Yasmin Rosa Santos +3 more
wiley +1 more source
International Journal of Applied Linguistics, EarlyView.ABSTRACT This study brings an interactional perspective to item reviewing (IR) as one of the critical language test construction stages by using conversation analysis. Drawing on video recordings of IR sessions in an English preparatory school at the tertiary level, it examines how EFL teachers problematize and revise syllabus‐based language test items
Hümeyra Can, Çiler Hatipoğlu
wiley +1 more source
Expert Asymmetry: Evidence From Securities Litigation
Journal of Empirical Legal Studies, EarlyView.ABSTRACT Modern litigation often involves two separate, extra‐legal features: (1) contingency fee arrangements with the plaintiff‐side attorney, and (2) a “battle of the experts” where the outcome of the case rests on conflicting expert witness testimony.
Adam Callister +2 more
wiley +1 more source
Journal of Phycology, EarlyView.Abstract Giant kelp (Macrocystis pyrifera) forests have declined by 95% in Australia since the 1970s due to climate change. Despite expanding restoration efforts, long‐term recovery is still lacking. Factors influencing recruitment by the microscopic gametophyte phase may represent a key mechanism underpinning the successful recovery and restoration of
Tamzin Gannon +8 more
wiley +1 more source