Results 181 to 190 of about 800,737 (240)

Severity of effect considerations regarding the use of mutation as a toxicological endpoint for risk assessment: A report from the 8th International Workshop on Genotoxicity Testing (IWGT)

Environmental and Molecular Mutagenesis, EarlyView.
Abstract Exposure levels without appreciable human health risk may be determined by dividing a point of departure on a dose–response curve (e.g., benchmark dose) by a composite adjustment factor (AF). An “effect severity” AF (ESAF) is employed in some regulatory contexts.
Barbara L. Parsons, Marc A. Beal, Kerry L. Dearfield, George R. Douglas, Min Gi, B. Bhaskar Gollapudi, Robert H. Heflich, Katsuyoshi Horibata, Michelle Kenyon, Alexandra S. Long, David P. Lovell, Anthony M. Lynch, Meagan B. Myers, Stefan Pfuhler, Alisa Vespa, Andreas Zeller, George E. Johnson, Paul A. White   +17 more
wiley   +1 more source

Comparative Evaluation of Open-Source Bioinformatics Pipelines for Full-Length Viral Genome Assembly. [PDF]

Viruses
Zsichla L, Zeeb M, Fazekas D, Áy É, Müller D, Metzner KJ, Kouyos RD, Müller V.   +7 more
europepmc   +1 more source

Consensus findings of an International Workshops on Genotoxicity Testing workshop on using transcriptomic biomarkers to predict genotoxicity

Environmental and Molecular Mutagenesis, EarlyView.
Abstract Gene expression biomarkers have the potential to identify genotoxic and non‐genotoxic carcinogens, providing opportunities for integrated testing and reducing animal use. In August 2022, an International Workshops on Genotoxicity Testing (IWGT) workshop was held to critically review current methods to identify genotoxicants using ...
Roland Froetschl, J. Christopher Corton, Henghong Li, Jiri Aubrecht, Scott S. Auerbach, Florian Caiment, Tatyana Y. Doktorova, Yurika Fujita, Danyel Jennen, Naoki Koyama, Matthew J. Meier, Roman Mezencev, Leslie Recio, Takayoshi Suzuki, Carole L. Yauk   +14 more
wiley   +1 more source

Improved reconstruction of single-cell developmental potential with CytoTRACE 2. [PDF]

Nat Methods
Kang M, Gulati GS, Brown EL, Qi Z, Avagyan S, Armenteros JJA, Gleyzer R, Zhang W, Steen CB, D'Silva JP, Schwab J, Clarke MF, Chaudhuri AA, Newman AM.   +13 more
europepmc   +1 more source

Finite Element Modeling of a Thermoplastic Polyurethane Ball for Rolling Seismic Isolation

Earthquake Engineering &Structural Dynamics, EarlyView.
ABSTRACT The Elastomeric‐Ball Pendulum (EBP) system, which consists of an elastomeric ball rolling on a spherical concrete surface, has been proposed as an isolation system for lightweight structures. Experimental tests have shown that the mechanics of such a rolling ball are remarkably complicated because the vertical load changes the shape of the ...
Sergio I. Reyes, Dimitrios Konstantinidis, Michalis F. Vassiliou   +2 more
wiley   +1 more source

Systematic Review of Hybrid Vision Transformer Architectures for Radiological Image Analysis. [PDF]

J Imaging Inform Med
Kim JW, Khan AU, Banerjee I.
europepmc   +1 more source

Seismic Design of Concrete Dams: An Integrated Risk‐Informed Performance‐Based (RIPB) Framework

Earthquake Engineering &Structural Dynamics, EarlyView.
ABSTRACT This paper advances the integration of risk‐informed principles into the seismic design of dams—a domain long guided by standards‐based, largely deterministic approaches. While performance‐based earthquake engineering is well established for buildings and bridges, its systematic adoption in dam engineering remains limited. We first address two
M. Amin Hariri‐Ardebili, Larry K. Nuss
wiley   +1 more source

Comparative benchmarking of single-cell clustering algorithms for transcriptomic and proteomic data. [PDF]

Genome Biol
Yin YH, Wang F, Li W, Liu Q, Zhou S, Zhou M, Jiang Z, Yu DJ, Wang G.   +8 more
europepmc   +1 more source

Time‐ and State‐Dependent Damage Accumulation Due to Aftershocks Under an M9.0 Megathrust Earthquake in the Cascadia Subduction Zone

Earthquake Engineering &Structural Dynamics, EarlyView.
ABSTRACT This study develops a comprehensive framework for assessing time and state‐dependent aftershock damage accumulation under an M9.0 megathrust interface earthquake in the Cascadia Subduction Zone (CSZ). The framework integrates aftershock probabilistic seismic hazard analysis (APSHA) and state‐dependent fragility analysis (SDFA) within a ...
Hongzhou Zhang, Yazhou Xie
wiley   +1 more source

Unraveling the Complexity of Divalent Hydride Electrolytes in Solid-State Batteries via a Data-Driven Framework with Large Language Model. [PDF]

Angew Chem Int Ed Engl
Wang Q, Yang F, Wang Y, Zhang D, Sato R, Zhang L, Cheng EJ, Yan Y, Chen Y, Kisu K, Orimo SI, Li H.   +11 more
europepmc   +1 more source