Results 31 to 40 of about 28,891 (208)

The professional-training-gap for adolescents in welfare dependent households

Journal for Labour Market Research
We examine how welfare benefit receipt influences the transition from school into all forms of professional training, including vocational training and higher education.
Julia Holleitner, Bernd Fitzenberger, Anna Heusler   +2 more
doaj   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

Just Transition or Just Illusion? A Critical Assessment of Climate and Development Programmes in Madagascar

Jurnal Ilmu Sosial dan Humaniora
Climate change impacts in Madagascar have intensified concerns about the fairness of current adaptation and development programmes, making the notion of a just transition an urgent policy and research priority.
Hoby Nasandratra Andriamiandrisoa, Ramalina Ranaivo Mikea Manitra   +1 more
doaj   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

Narrative risk messages increase uptake and sharing of health interventions in a hard-to-reach population: A pilot study to promote milk safety among Maasai pastoralists in Tanzania

Pastoralism, 2019
Across pastoralist groups, dairy products often fulfill major nutritional, economic, and socio-cultural functions. These contributions are jeopardized by poor milk quality with studies among pastoralist groups showing dairy products can harbour a long ...
Mark A. Caudell, P. Victor Charoonsophonsak, Annalise Miller, Beatus Lyimo, Murugan Subbiah, Joram Buza, Douglas R. Call   +6 more
doaj   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Sustainable livelihood opportunities for tribal communities through inclusive ecotourism

Discover Sustainability
Eco-tourism is increasingly promoted as a sustainable development strategy that can simultaneously advance environmental conservation and enhance the livelihoods of indigenous communities.
Megha Bhatt, Sahil Singh Jasrotia, Shagun Chib, Vijay Amrit Raj   +3 more
doaj   +1 more source

Thermal Stress, Energy Anxiety, and Vulnerable Households in a Just Transition Region: Evidence from Western Macedonia, Greece

World
This study investigates thermal stress and energy-related anxiety as lived, multidimensional manifestations of energy poverty in Western Macedonia, Greece, a coal phase-out region undergoing just transition.
Stavros P. Migkos, Androniki Katarachia, Polytimi M. Farmaki   +2 more
doaj   +1 more source