Results 71 to 80 of about 332,234 (284)

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

open access: yesFEBS Letters, EarlyView.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman   +2 more
wiley   +1 more source

Implementing access and benefit sharing in eight countries [PDF]

open access: yes, 2016
Since 2012, national teams in eight countries in Asia, Africa and Latin America have been identifying options for policy, legal and administrative mechanisms for the implementation of the multilateral system of access and benefit sharing (MLS) for plant ...
Bessette, G.   +6 more
core  

Toward Global Justice through Benefit-Sharing [PDF]

open access: yesHastings Center Report, 2010
Biopiracy" is a critical term coined to describe the practice of "bioprospecting," which falls short of today's ethical and legal standards. While bioprospecting is the age-old search for natural chemical products, biopiracy conjures up lurid images of ruthless perpetrators, ill-gotten riches, and plundered victims.
openaire   +2 more sources

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

open access: yesMolecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham   +21 more
wiley   +1 more source

Benefit and Cost Analysis of Resource Sharing

open access: yesInternational Journal of Librarianship
Libraries are not exempt from rising costs. The situation presented is how libraries can continue to provide services while also finding efficiencies in labor and operational expenditures.
Cherie Weible, Janelle Sander
doaj   +1 more source

TRANSBOUNDARY WATER COOPERATION IN AFRICA: THE CASE OF THE NILE BASIN INITIATIVE (NBI) [PDF]

open access: yes
The aim of this paper is to identify the economic, social and political benefits of the transboundary cooperation by using the Nile Bain Initiative (NBI) as a case study. It also attempts to identify the obstacles that hinder transboundary cooperation in
Wondwosen TESHOME
core  

Characterizing the salivary RNA landscape to identify potential diagnostic, prognostic, and follow‐up biomarkers for breast cancer

open access: yesMolecular Oncology, EarlyView.
This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan   +9 more
wiley   +1 more source

Property rights and benefit sharing: a case study of the Barotse floodplain of Zambia

open access: yesInternational Journal of the Commons, 2016
The study sought to expose the underlying complexity of benefit sharing of ecosystem goods and services among multiple actors in the Barotse Floodplains of Zambia.
Machaya Jeff Chomba, Bimo Abraham Nkhata
doaj   +1 more source

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