Results 61 to 70 of about 1,862,201 (299)
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
Next‐generation proteomics improves lung cancer risk prediction
Molecular Oncology, EarlyView.This is one of very few studies that used prediagnostic blood samples from participants of two large population‐based cohorts. We identified, evaluated, and validated an innovative protein marker model that outperformed an established risk prediction model and criteria employed by low‐dose computed tomography in lung cancer screening trials.
Megha Bhardwaj +4 more
wiley +1 more source
Revista Derecho del Estado, 2018 How to define sharing benefits from Marine Genetic Resources in the High Seas (water column) as equitable and just? Supposedly, the United Nations Convention on the Law of the Sea, international custom and the Convention on Biological Diversity do not ...
Sergio Peña Neira
doaj +1 more source
Capacity Building Workshop on Genetic Resource Policies for CGIAR Scientists and Partners in East Africa, 4 - 7 June 2019, ILRI Campus, Addis Ababa, Ethiopia [PDF]
, 2020 The CGIAR Genebank Platform Policy Module, in coordination with the International Livestock Research Institute (ILRI), organized the ‘Capacity building workshop on genetic resource policies for CGIAR scientists and partners in East Africa’.
CGIAR Genebank Platform
core
Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib
Molecular Oncology, EarlyView.WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute +17 more
wiley +1 more source
Equilibrium unemployment under negotiated profit sharing [PDF]
We study employment, employee effort, wages and profit sharing when firms face stochastic revenue shocks and when base wages and profit shares are determined through collective bargaining.
Koskela, Erkki, Stenbacka , Rune
core +3 more sources
Meanings and robustness: Propositions for enhancing benefit sharing in social-ecological systems
International Journal of the Commons, 2014 Given increased pressure on natural resources to deliver benefits, complex trade-offs and the regulation of behaviours in relation to benefits is of key concern.
Ernita van Wyk +2 more
doaj +1 more source
Gratitude depends on the relational model of communal sharing. [PDF]
PLoS ONE, 2014 We studied the relation between benefits, perception of social relationships and gratitude. Across three studies, we provide evidence that benefits increase gratitude to the extent to which one applies a mental model of a communal relationship.
Cláudia Simão, Beate Seibt
doaj +1 more source
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
Bringing access and benefit sharing into the digital age
Plants, People, Planet, 2022 Societal Impact Statement Reading and writing DNA is now possible with an unprecedented speed and ease. To catch up with digitization of genetic resources, scientists need to join with all relevant stakeholders and design new global governance mechanisms
Sylvain Aubry +8 more
doaj +1 more source